Chercheurs

Sciences de la Vie / METHERATE, RAJU

raju.metherate

Position

Associate Professor, Neurobiology and Behavior School of Biological Sciences,

Director, Center for Hearing Research, Department of Neurobiology and Behavior, University of California, Irvine, CA, US.

Thèmes de recherche

Neurophysiology, Synaptic physiology of auditory cortex

Research interest in learning and memory : the research goal of his laboratory is to understand how our brains perceive sounds. They study neurons in the auditory cortex to determine how they communicate with each other, how interneuron communication underlies auditory information processing, and how it can be modified, for example, during learning and memory. One recent study suggests that the development of the auditory cortex may be altered by passive ("secondhand") exposure to nicotine.

Prix et récompenses

Publications

Kawai, H, Lazar, R. and Metherate, R. Nicotinic control of axon excitability regulates thalamocortical transmission. Nature Neuroscience (in press).

Liang, K., Poytress, B.S., Chen, Y., Leslie, F.M., Weinberger, N.M. and Metherate, R. (2006) Neonatal nicotine exposure impairs nicotinic enhancement of central auditory processing and auditory learning in adult rats. European Journal of Neuroscience 24: 857-866.

Rose, H.J., and Metherate, R. (2005) Auditory thalamocortical transmission is reliable and temporally precise. Journal of Neurophysiology 94:2019-2030.

Kaur, S., Rose, H.J., Lazar, R., Liang, K. and Metherate, R. (2005) Spectral integration in primary auditory cortex: laminar processing of afferent input, in vivo and in vitro. Neuroscience 134:1033-1045.

Metherate, R., Kaur, S., Kawai, H., Lazar, R., Liang, K., Rose, H.J. (2005) Spectral integration in auditory cortex: mechanisms and modulation. Hearing Research 206:146-158.

Kaur, S., Lazar, R. and Metherate, R. (2004) Intracortical pathways determine breadth of subthreshold frequency receptive fields in primary auditory cortex. Journal of Neurophysiology 91:2551-2567

Metherate, R. (2004) Nicotinic acetylcholine receptors in sensory cortex. Learning & Memory 11:50-59.

Cruikshank, S.J., Rose, H.J. and Metherate, R. (2002) Auditory thalamocortical synaptic transmission, in vitro. Journal of Neurophysiology 87:361-84.

Aramakis, V.B., Hsieh, C.Y., Leslie, F.M. and Metherate, R. (2000) A critical period for nicotine-induced disruption of synaptic development in rat auditory cortex. Journal of Neuroscience 20:6106-6116.

Aramakis, V.B. and Metherate, R. (1998) Nicotine selectively enhances NMDA receptor-mediated synaptic transmission during postnatal development in sensory neocortex. Journal of Neuroscience 18:8485-8495.