Chercheurs

Sciences de la Vie / FINLAY, BRETT.B

bfinlay

Position

Professor in the Michael Smith Laboratories and the Departments of Biochemistry and Molecular Biology, and Microbiology and Immunology at the University of British Columbia, Vancouver, British Columbia, Canada.

Thèmes de recherche

Dr. Finlay’s research interests are focussed on host-pathogen interactions, at the molecular level. By combining cell biology with microbiology, he has been at the forefront of the emerging field called Cellular Microbiology, making several fundamental discoveries in this field, and publishing over 250 papers.

In 1997, Dr. Finlay discovered how the E.coli 0157:H7 bacterium binds to its host cell. He later developed a vaccine for cattle that is successfully destroying this strain of the bacterium, reducing the human toll of E. coli outbreaks such as the one that took place in Walkerton, Ontario in the summer of 2000.

He is a cofounder of Inimex Pharmaceuticals, Inc., and Director of the SARS Accelerated Vaccine Initiative. He also serves on several editorial and advisory boards, and is a strong supporter of communicating science to the public.

Prix et récompenses

He has won several prestigious awards including the E.W.R. Steacie Prize, the CSM Fisher Scientific Award, a MRC Scientist, five Howard Hughes International Research Scholar Awards, a CIHR Distinguished Investigator, BC Biotech Innovation Award, the Michael Smith Health Research Prize, the IDSA Squibb Award, the Jacob Biely Prize. He is a Fellow of the Royal Society of Canada and the Canadian Academy of Health Sciences, and is the UBC Peter Wall Distinguished Professor.

Publications

Wickham ME, Brown NF, Boyle EC, Coombes BK, Finlay BB. Virulence is positively selected by transmission success between mammalian hosts. Curr Biol. 2007 May 1;17(9):783-8. Epub 2007 Apr 19.

Guttman JA, Kazemi P, Lin AE, Vogl AW, Finlay BB. Desmosomes are unaltered during infections by attaching and effacing pathogens. Anat Rec (Hoboken). 2007 Feb;290(2):199-205.

Mason D, Mallo GV, Terebiznik MR, Payrastre B, Finlay BB, Brumell JH, Rameh L, Grinstein S. Alteration of epithelial structure and function associated with PtdIns(4,5)P2 degradation by a bacterial phosphatase. J Gen Physiol. 2007 Apr;129(4):267-83.

Scott MG, Dullaghan E, Mookherjee N, Glavas N, Waldbrook M, Thompson A, Wang A, Lee K, Doria S, Hamill P, Yu JJ, Li Y, Donini O, Guarna MM, Finlay BB, North JR, Hancock RE. An anti-infective peptide that selectively modulates the innate immune response. Nat Biotechnol. 2007 Apr;25(4):465-72.

Wickham ME, Lupp C, Vazquez A, Mascarenhas M, Coburn B, Coombes BK, Karmali MA, Puente JL, Deng W, Finlay BB. Citrobacter rodentium virulence in mice associates with bacterial load and the type III effector NleE. Microbes Infect. 2007 Mar;9(3):400-7.

Zarivach R, Vuckovic M, Deng W, Finlay BB, Strynadka NC. Structural analysis of a prototypical ATPase from the type III secretion system. Nat Struct Mol Biol. 2007 Feb;14(2):131-7.

Bishop JL, Boyle EC, Finlay BB. Deception point: peptidoglycan modification as a means of immune evasion. Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):691-2.

Boyle EC, Bishop JL, Grassl GA, Finlay BB. Salmonella: from pathogenesis to therapeutics. J Bacteriol. 2007 Mar;189(5):1489-95. Epub 2006 Dec 22. Review.

Grassl GA, Finlay BB. Shigella rewrites host transcriptional responses. Nat Immunol. 2007 Jan;8(1):15-6.

Jandu N, Shen S, Wickham ME, Prajapati R, Finlay BB, Karmali MA, Sherman PM. Multiple seropathotypes of verotoxin-producing Escherichia coli (VTEC) disrupt interferon-gamma-induced tyrosine phosphorylation of signal transducer and activator of transcription (Stat)-1. Microb Pathog. 2007 Feb-Mar;42(2-3):62-71.

Coombes BK, Lowden MJ, Bishop JL, Wickham ME, Brown NF, Duong N, Osborne S, Gal-Mor O, Finlay BB. SseL is a salmonella-specific translocated effector integrated into the SsrB-controlled salmonella pathogenicity island 2 type III secretion system. Infect Immun. 2007 Feb;75(2):574-80.

Coburn B, Grassl GA, Finlay BB. Salmonella, the host and disease: a brief review. Immunol Cell Biol. 2007 Feb-Mar;85(2):112-8. Review.

Vaid KS, Guttman JA, Babyak N, Deng W, McNiven MA, Mochizuki N, Finlay BB, Vogl AW. The role of dynamin 3 in the testis. J Cell Physiol. 2007 Mar;210(3):644-54.