Chercheurs

Médecine / PRICE, RIC

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Position

Consultant Physician in Infectious Diseases and General Medicine,

Senior Research Fellow, Menzies School of Health Research;
Honorary Lecturer in Tropical Medicine, Oxford University

Thèmes de recherche

- Risk factors, clinical consequences and strategies for treatment and prevention of drug resistant falciparum malaria.
- Correlating in vivo, in vitro and molecular markers of drug resistance.
- Chemotherapeutic drug studies; in particular investigation of the use of artemisinin derivatives for the treatment of falciparum malaria.
- Population pharmacokinetics and mathematical modelling of parasite response following antimalarial therapy.

Prix et récompenses

Fellow of the Royal Society of Tropical Medicine and Hygiene

Member of the Australasian Society of Infectious Diseases.

Publications

Price RN, Nosten F, Luxemburger C, ter Kuile FO, Chongsuphajaisiddhi T and White NJ. Effects of artemisinin derivatives on malaria transmissibility. The Lancet; (347): 1654-1658, 1996.

Price RN, Nosten F, Luxemburger C, van Vugt M, Phaipun L, Chongsuphajaisiddhi T and White NJ. Artesunate / mefloquine treatment of multi-drug resistant falciparum malaria. Transactions of The Royal Society Of Tropical Medicine and Hygiene; (91): 574-577, 1997.

Price RN, Luxemburger C, van Vugt M, Simpson J, Phaipun L, Chongsuphajaisiddhi T, Nosten F and White NJ. Artesunate and mefloquine in the treatment of uncomplicated multidrug- resistant hyperparasitaemic falciparum malaria. Transactions of The Royal Society Of Tropical Medicine and Hygiene; (92): 207-211, 1998.

Price RN, van Vugt M, Luxemburger C, Brockman A, Phaipun L, Chongsuphajaisiddhi T, Nosten F and White NJ. Artesunate versus artemether for the treatment of recrudescent falciparum malaria. American Journal of Tropical Medicine and Hygiene; (59): 883-888, 1998.

Price RN, van Vugt M, Phaipun L, Luxemburger C, Simpson J, McGreedy M, ter Kuile FO, Am Kham, Chongsuphajaisiddhi T, White NJ and Nosten F. Adverse effects in patients with acute falciparum malaria treated with artemisinin derivatives. American Journal of Tropical Medicine and Hygiene; 60(4): 547-555, 1999.

Price RN, Simpson J, Teja-Isavatharm P, Luxemburger C, Than MM, Heppner DG, Chongsuphajaisiddhi T, Nosten F and White NJ. Pharmacokinetics of mefloquine combined with artesunate in children with acute falciparum malaria. Antimicrobial Agents and Chemotherapy; (43): 341-346, 1999.

Price RN, Cassar C, Brockman A, Duraisingh M, van Vugt M, White NJ, Nosten F, Krishna S. The pfmdr1 gene is associated with a multidrug resistance phenotype in Plasmodium falciparum from the Western border of Thailand. Antimicrobial Agents and Chemotherapy; 43(12): 2943-2949, 1999.

Nosten F, van Vugt M, Price R, Luxemburger C, Brockman A, McGready R, ter Kuile FO, Looareesuwan S, White NJ. The effects of combining artesunate with mefloquine on the incidence of falciparum malaria and the evolution of drug resistance. The Lancet; (356): 297-302, 2000.

Simpson JA, Watkins E, Price RN, Aarons L, Kyle D, Looareesuwan S, White NJ. Mefloquine pharmacokinetics-pharmacodynamic models: implications for dosing and resistance. Antimicrobial Agents and Chemotherapy; (44): 3414-3424, 2000.

Price RN, Simpson J, Nosten F, Luxemburger C, Hkirjaroen L, ter Kuile FO, Chongsuphajaisiddhi T and White NJ. Factors contributing to anaemia following uncomplicated falciparum malaria. American Journal of Tropical Medicine and Hygiene; 65(5): 614-622, 2001.

Reviews

Nosten F and Price RN. A Risk-Benefit Assessment of Newer Antimalarials. Drug Safety; 12 (4): 264 - 273, 1995. Price RN. Artemisinin Drugs: Novel Antimalarial Agents. Expert Opinion on Investigational Drugs; 9(8) :1815-1827, 2000.

Price RN. The use of antimalarial drug combinations containing an artemisinin derivative for the treatment of falciparum malaria. South Eastern Journal Of Tropical Medicine; 31 (Suppl 1): 1-3, 2001.

Price RN and Nosten F. Drug resistant falciparum malaria: clinical consequences and strategies for prevention. Drug Resistant Updates; 4: 187-196, 2001.

Book Chapters

Krishna S, Price RN and Riberio I.Antiprotozoal Drugs; in Meyler’s Side Effects of Drugs Annual 1998. n