Chercheurs

Sciences de la Vie / BOURNE, PHILIP E.

bourne

Position

Professor in the Department of Pharmacology at the University of California San Diego
La Jolla CA, U.S.A.

Co-director of the Protein Data Bank and an Adjunct Professor at the Burnham Institute for Medical Research and the Keck Graduate Institute.

Past President of the International Society for Computational Biology.

Thèmes de recherche

Bourne's professional interests focus on bioinformatics and structural bioinformatics in particular. This implies algorithms, metalanguages, biological databases, biological query languages and visualization with special interest in evolution, cell signaling and apoptosis.

Prix et récompenses

2004 : Editor-in-Chief PLoS Computational Biology
2004 : Flinders University Convocation Medal for Outstanding Achievement
2004 : Editor, Transactions on Computational Biology and Bioinformatics
2003 : Associate Editor, Bioinformatics
2003 : Chair, Publications Committee, International Society for Computational Biology
2003 : Editor, Proteins, Structure, Function and Bioinformatics
2003 : Advisory Editorial Board, Biosilico
2003 : Member, US National Committee for Crystallography
2002 : President, International Society for Computational Biology
2002 : Elected Fellow, American Medical Informatics Association
2001 : Author of second most cited paper in biology for 2000 according to Science Watch
2001 : Advisory Board, Biopolymers
2000-2002 : Editor, Bioinformatics
2000-2001 : Secretary, International Society for Computational Biology
1999-2001 : AAAS Representative for the American Crystallography Association
1997-2002 : Editor (Web Alert) Current Opinions in Structural Biology
1996-1998 : Chairman American Crystallography Association Computing Committee
1996 & 1997 : UCSD Connect Award for New Inventions
1996-1999 : Chairman International Union of Crystallography Computing Commission
1996 : Member NSF review panel for Biological Databases
1994 : Editor - International Union of Crystallography mmCIF Data Standard

Publications

P.E.Bourne, H.M.Berman, B.M.McMahon, K. Watenpaugh, J.Westbrook & P.M.D.Fitzgerald (1997) The Macromolecular CIF (mmCIF) Dictionary. Meth. in Enzymology 277, 571-590. The Macromolecular CIF Dictionary (mmCIF)..

C. Smith, M. Gribskov, I.N. Shindyalov, S.S Taylor, L. Ten Eyck, S. Veretnik, P.E.Bourne TIBS (1997) 22(11) 444-446. The Protein Kinase Resource (PKR).

I.N. Shindyalov and P.E. Bourne Protein Engineering (1998) 11(9) 739-747. Protein Structure Alignment by Incremental Combinatorial Extension of the Optimum Path.

H. Weissig and P.E. Bourne Acta Cryst. D (1998) D54 1085-1094. Temporal and Global Characteristics of Macromolecular Structure Data as Determined by X-ray Crystallography.

H.M. Berman, J. Westbrook, Z. Feng, G. Gilliland, T.N. Bhat, H. Weissig, I.N. Shindyalov, and P.E. Bourne Nucleic Acid Research 2000 28(1), 235-242. The Protein Data Bank

Tsigelny1, I. N. Shindyalov, P. E. Bourne, T. Südhof and P. Taylor 2000 Protein Science 8 1-6 Common EF-hand Motifs in Cholinesterases and Neuroligins Suggest a Role for CA2+ Binding in Cell Surface Associations.

J.D. Westbrook and P.E. Bourne 2000 Bioinformatics 16(2) 159-168. STAR/mmCIF: An Extensive Ontology for Macromolecular Structure and Beyond.

I.N. Shindyalov and P.E. Bourne 2000 Proteins: Structure, Function and Genetics 38(3), 247-260. An Alternative View of Protein Fold Space.

B.V.B Reddy, W. Li, I.N. Shindyalov, and P.E. Bourne 2001 Proteins: Structure, Function and Genetics 42(2) 148-163. Conserved key amino acid positions (CKAAPs) derived from the analysis of common substructures in proteins.

K. Baldridge and P.E. Bourne 2002, The New Biology and the Grid. Chapter 40 pp 907-922 from Grid Computing - Making the Global Infrastructure a Reality (eds) F.Berman, G. Fox and T.Hey Wiley, New York.

P.E. Bourne 2002 Science's Policy on Data Deposition. Science 296, 1609.

J.V. Ponaramenko, I.N. Shindyalov and P.E. Bourne 2002 Building an Automated Classification of DNA-binding Protein Domains. Bioinformatics 18:S192-201.

P.E.Bourne 2003 Free access to publicly funded databases is vital. Nature 421, 786.

P. Yang, P.A. Craig, D. Goodsell and P.E. Bourne 2003 BioEditor - Simplifying Macromolecular Structure Annotation. Bioinformatics 19(7) 897-898.

K.S. Doctor, J. Reed, A. Godzik and P.E.Bourne 2003 The Apoptosis Database. Cell Death and Differentiation 10(6), 621-633.

W.W. Li, G.B. Quinn, N. N. Alexandrov, P.E. Bourne and I.N. Shindyalov 2003 Proteins of Arabidopsis thaliana (PAT) database: A resource for comparative proteomics. Genome Biology 4(8), R51.

S. Verentik, P.E. Bourne, N.N. Alexandrov, I.N. Shindyalov 2003 Towards consistent assignment of structural domains in proteins. Journal of Molecular Biology, 339(3):647-78.

J.V. Ponomarenko, P.E. Bourne and I.N. Shindyalov 2005 Assigning New GO Annotations to Protein Data Bank Sequences by Structural Homology. Proteins: Structure, Function and Bioinformatics. 58: 855-865.

S. Yang, R.F. Doolittle and P.E. Bourne 2005 Phylogeny Studied Through Protein Domain Content. PNAS 102(2): 373-378

E. Scheeff and P.E. Bourne 2005 Structural Evolution of the Protein Kinase-Like Superfamily PLoS Computational Biology. Submitted..

J-L Chung, W. Wang and P.E. Bourne 2005 Exploiting Sequence and Structure Homology to Find Protein-Protein Binding Sites Proteins: Structure, Function and Bioinformatics. Submitted.