Chercheurs

Médecine / TILL, JAMES E.

till

Position

Senior Scientist
Division of Epidemiology, Statistics & Behaviour
University of Toronto
Ontario Cancer Institute,
Ontario, Canada.

Thèmes de recherche

Biophysics, Cancer Or Carcinogenesis, Cell Biology, Communications, Decision Sciences, Epidemiology, Informatics, Medical Decision Making, Medical Ethics, Medical Informatics, Medical Physics, Oncology, Stem Cells.

His major continuing interest is in research relevant to cancer control, with a particular emphasis on cross-disciplinary research.

A current interest is in ways that the Internet can foster knowledge transfer in general, and the dissemination of the results of high-quality research in particular. An important example is the 'Open Access Movement', designed to permit open access (OA) to peer-reviewed research publications, and especially publications based on research that's been supported from public funds.

The traditional subscription-based approaches to the publication of peer-reviewed research are highly inequitable, because much of this research is published in expensive journals that may not be accessible to the researchers, practitioners, policy makers, entrepreneurs and members of the media and the public to whom the findings are particularly relevant.

Prix et récompenses

2005 : Albert Lasker Basic Medical Research Award (with E.A. McCulloch), Albert and Mary Lasker Foundation
2005 : Biomedical Science Ambassador Award (with E.A. McCulloch), Partners in Research
2005 : Centenary Medal (with E.A. McCulloch), Royal Society of Canada
2004 : The Canadian Medical Hall of Fame (with E.A. McCulloch)
2004 : ., (Honorary), University of Toronto
2001 : R.M. Taylor Medal, Canadian Cancer Society/National Cancer Institute of Canada
2000 : Fellow, Royal Society of London (UK)
1997 : University Professor Emeritus University of Toronto
1994 : Officer of the Order of Canada,
1993 : Robert L. Noble Prize National Cancer Institute of Canada
1991 : Thomas W. Eadie Medal, Royal Society of Canada (with E.A. McCulloch),
1984-1997, University Professor, University of Toronto,
1969 : Fellow, Royal Society of Canada
1969 : Gairdner Foundation International Award (with E.A. McCulloch)

Publications

McCulloch EA, Till JE, Perspectives on the Properties of Stem Cells (), Nature Medicine, 11(10), 1026-8, Oct 2005

Till JE, Cancer-related Electronic Support Groups As Navigation-aids: Overcoming Geographic Barriers (), Journal of Cancer Integrative Medicine, 2(1), 21-24, 01 Jan 2004

Till JE, Evaluation of support groups for women with breast cancer: importance of the navigator role, Health and Quality of Life Outcomes (), 1(1), 16, 1 May 2003

Till JE, Phillips RA, Jadad AR, Finding Canadian cancer clinical trials on the Internet: an exploratory evaluation of online resources, Cmaj : Canadian Medical Association Journal = Journal De L'association Medicale Canadienne., 168(9), 1127-9, April 2003

Till JE, Success factors for open access, Journal of Medical Internet Research [electronic Resource], 5(1), E1, 2003

Eysenbach G, Till JE, Ethical issues in qualitative research on internet communities, Bmj (clinical Research Ed.), 323(7321), 1103-5, November 2001

Till JE, Predecessors of preprint servers (eprint: ), Learned Publishing, 14(1), 7-13, Jan 2001

Till JE, Peer review in a post-eprints world: a proposal, Journal of Medical Internet Research [electronic Resource], 2(3), E14, 2000

Till JE, Harold Elford Johns 1915-1998, Proceedings of the Royal Society of Canada, XI(Sixth Series), 121-124, 2000

Sutherland HJ, da Cunha R, Lockwood GA, Till JE, What attitudes and beliefs underlie patients' decisions about participating in chemotherapy trials? (PDF via: ), Medical Decision Making, 18(1), 61-9, 01 Jan 1998

Till JE, An introduction to the framework project, Cancer Prevention and Control, 1(3), 192-5, August 1997

Langley GR, Minkin S, Till JE, Regional variation in nonmedical factors affecting family physicians' decisions about referral for consultation, Cmaj, 157(3), 265-72, August 1997

Mayer M, Till JE, The Internet: a modern Pandora's box?, Quality of Life Research, 5(6), 568-71, December 1996

Cormack DV, Fisher PM, Till JE, A study of waiting times and waiting lists for radiation therapy patients, Canadian Journal of Oncology, 6(1), 427-34, June 1996

Till JE, Discussion groups on the Internet: where to begin?, Canadian Journal of Oncology, 5(3), 377-8, September 1995

Till JE, Discussion groups on the Internet: journaling, Canadian Journal of Oncology, 5(3), 379-80, September 1995

Osoba D, Till JE, Pater JL, Young JR, Health-related quality of life: measurement and clinical application. A workshop report, Canadian Journal of Oncology, 5(1), 338-43, March 1995

Meslin EM, Sutherland HJ, Lavery JV, Till JE, Principlism and the ethical appraisal of clinical trials, Bioethics, 9, 399-418, 1995

Till JE, Osoba D, Pater JL, Young JR, Research on health-related quality of life: dissemination into practical applications, Quality of Life Research, 3(4), 279-83, August 1994

Sutherland HJ, Till JE, Opinion polling and decision making: a critical appraisal of quality of life assessment, Quality of Life Research, 3(2), 155-62, April 1994

Till JE, Measuring quality of life: apparent benefits, potential concerns, Canadian Journal of Oncology, 4(1), 243-8, January 1994

Meslin EM, Lavery JV, Sutherland HJ, Till JE, Judging the clinical merit of clinical trials: what criteria do research ethics board members use?, IRB, 16(4), 6-10, 1994

Sutherland HJ, Meslin EM, Till JE, What's missing from current clinical trial guidelines? A framework for integrating science, ethics, and the community context, Journal of Clinical Ethics, 5(4), 297-303, Winter 1994

Sutherland HJ, Meslin EM, da Cunha R, Till JE, Judging clinical research questions: what criteria are used?, Social Science and Medicine, 37(12), 1427-30, December 1993

Sutherland HJ, Carlin K, Harper W, Martin LJ, Greenberg CV, Till JE, Boyd NF, A study of diet and breast cancer prevention in Canada: why healthy women participate in controlled trials, Cancer Causes and Control, 4(6), 521-8, November 1993

Sutherland HJ, Till JE, Quality of life assessments and levels of decision making: differentiating objectives, Quality of Life Research, 2(4), 297-303, August 1993

Till JE, Sutherland HJ, Meslin EM, Is there a role for preference assessments in research on quality of life in oncology?, Quality of Life Research, 1(1), 31-40, February 1992

Till JE, Quality of life measurements in cancer treatment, Important Advances in Oncology, 189-204, 1992

Degner LF, Jerry LM, Till JE, Communication in cancer: report on the Terry Fox Workshop [editorial], Cmaj, 144(11), 1417-8 1421-3, June 1991

Sutherland HJ, Lockwood GA, Tritchler DL, Sem F, Brooks L, Till JE, Communicating probabilistic information to cancer patients: is there 'noise' on the line?, Social Science and Medicine, 32(6), 725-31, 1991

Langley GR, Tritchler DL, Llewellyn-Thomas HA, Till JE, Use of written cases to study factors associated with regional variations in referral rates, Journal of Clinical Epidemiology, 44(4-5), 391-402, 1991

* Sutherland HJ, Lockwood GA, Till JE, Are we getting informed consent from patients with cancer?, Journal of the Royal Society of Medicine, 83(7), 439-43, July 1990

* Sutherland HJ, Llewellyn-Thomas HA, Lockwood GA, Tritchler DL, Till JE, Cancer patients: their desire for information and participation in treatment decisions, Journal of the Royal Society of Medicine, 82(5), 260-3, May 1989

Sutherland HJ, Lockwood GA, Minkin S, Tritchler DL, Till JE, Llewellyn-Thomas HA, Measuring satisfaction with health care: a comparison of single with paired rating strategies, Social Science and Medicine, 28(1), 53-8, 1989

Sutherland HJ, Walker P, Till JE, The development of a method for determining oncology patients' emotional distress using linear analogue scales, Cancer Nursing, 11(5), 303-8, October 1988

O'Connor AM, Boyd NF, Warde P, Stolbach L, Till JE, Eliciting preferences for alternative drug therapies in oncology: influence of treatment outcome description, elicitation technique and treatment experience on preferences, Journal of Chronic Diseases, 40(8), 811-8, 1987

Ciampi A, Kates L, Buick R, Kriukov Y, Till JE, Multi-type Galton-Watson process as a model for proliferating human tumour cell populations derived from stem cells: estimation of stem cell self-renewal probabilities in human ovarian carcinomas, Cell and Tissue Kinetics, 19(2), 129-40, March 1986

O'Connor AM, Boyd NF, Tritchler DL, Kriukov Y, Sutherland H, Till JE, Eliciting preferences for alternative cancer drug treatments. The influence of framing, medium, and rater variables, Medical Decision Making, 5(4), 453-63, Winter 1985

Llewellyn-Thomas H, Sutherland HJ, Tibshirani R, Ciampi A, Till JE, Boyd NF, Describing health states. Methodologic issues in obtaining values for health states, Medical Care, 22(6), 543-52, June 1984

Roncari DA, Salter RB, Till JE, Lowy FH, Is the clinician-scientist really vanishing? Encouraging results from a Canadian institute of medical science, Canadian Medical Association Journal, 130(8), 977-9, April 1984

Till JE, McNeil BJ, Bush RS, Measurement of multiple components of quality of life, Cancer Treatment Symposia, 1, 177-81, 1984

Mackillop WJ, Ciampi A, Till JE, Buick RN, A stem cell model of human tumor growth: implications for tumor cell clonogenic assays, Journal of the National Cancer Institute, 70(1), 9-16, January 1983

Llewellyn-Thomas H, Sutherland HJ, Tibshirani R, Ciampi A, Till JE, Boyd NF, The measurement of patients' values in medicine, Medical Decision Making, 2(4), 449-62, Winter 1982

Sutherland HJ, Llewellyn-Thomas H, Boyd NF, Till JE, Attitudes toward quality of survival. The concept of 'maximal endurable time', Medical Decision Making, 2(3), 299-309, 1982

Ciampi A, Bush RS, Gospodarowicz M, Till JE, An approach to classifying prognostic factors related to survival experience for non-Hodgkin's lymphoma patients: based on a series of 982 patients: 1967-1975, Cancer, 47(3), 621-7, February 1981

Till JE, Cellular diversity in the blood-forming system, American Scientist, 69(5), 522-7, 1981

Till JE, McCulloch EA, Hemopoietic stem cell differentiation, Biochimica Et Biophysica Acta, 605(4), 431-59, November 1980

Ciampi A, Till JE, Null results in clinical trials: the need for a decision-theory approach, British Journal of Cancer, 41(4), 618-29, April 1980

Curtis JE, Till JE, Messner HA, Sousan P, McCulloch EA, Comparison of outcomes and prognostic factors for two groups of patients with acute myeloblastic leukemia, Leukemia Research, 3(6), 409-16, 1979

Minden MD, Till JE, McCulloch EA, Proliferative state of blast cell progenitors in acute myeloblastic leukemia (AML), Blood, 52(3), 592-600, September 1978

Lan S, McCulloch EA, Till JE, Cytodifferentiation in the acute myeloblastic leukemias of man, Journal of the National Cancer Institute, 60(2), 265-9, February 1978

Niederer J, Hawkins NV, Rider WD, Till JE, Failure analysis of radical radiation therapy of supraglottic laryngeal carcinoma, International Journal of Radiation Oncology, Biology, Physics, 2(7-8), 621-9, 1977

Carlsen SV, Till JE, Ling V, Modulation of drug permeability in Chinese hamster ovary cells. Possible role for phosphorylation of surface glycoproteins, Biochimica Et Biophysica Acta, 467(2), 238-50, June 1977

Buick RN, Till JE, McCulloch EA, Colony assay for proliferative blast cells circulating in myeloblastic leukaemia [letter], Lancet, 1(8016), 862-3, April 1977

Bech-Hansen NT, Till JE, Ling V, Pleiotropic phenotype of colchicine-resistant CHO cells: cross-resistance and collateral sensitivity, Journal of Cellular Physiology, 88(1), 23-31, May 1976

Till JE, Price GB, Mak TW, McCulloch EA, Regulation of blood cell diferentiation, Federation Proceedings, 34(13), 2279-84, December 1975

Gregory CJ, McCulloch EA, Till JE, Transient erythropoietic spleen colonies: effects of erythropoietin in normal and genetically anemic W/Wv mice, Journal of Cellular Physiology, 86(1), 1-8, August 1975

Niho Y, Till JE, McCulloch EA, Granulopoietic progenitors in suspension culture: a comparison of stimulatory cells and conditioned media, Blood, 45(6), 811-21, June 1975

Till JE, Bruce WR, Elwan A, Till MJ, Niederer J, Reid J, Hawkins NV, Rider WD, A preliminary analysis of end results for cancer of the larynx, Laryngoscope, 85(2), 259-75, February 1975

Aye MT, Till JE, McCullouch EA, Cytological studies of colonies in culture derived from the peripheral blood cells of two patients with acute leukemia, Experimental Hematology, 2(6), 362-71, 1974

Baker RM, Brunette DM, Mankovitz R, Thompson LH, Whitmore GF, Siminovitch L, Till JE, Ouabain-resistant mutants of mouse and hamster cells in culture, Cell, 1(1), 9-21, 1974

Gregory CJ, McCulloch EA, Till JE, Erythropoietic progenitors capable of colony formation in culture: state of differentiation, Journal of Cellular Physiology, 81(3), 411-20, June 1973

Korn AP, Henkelman RM, Ottensmeyer FP, Till JE, Investigations of a stochastic model of haemopoiesis, Experimental Hematology, 1(6), 362-75, 1973

Till JE, Baker RM, Brunette DM, Ling V, Thompson LH, Wright JA, Genetic regulation of membrane function in mammalian cells in culture, Federation Proceedings, 32(1), 29-33, January 1973 Abstract

Messner H, Till JE, McCulloch EA, Density distributions of marrow cells from mouse and man, Series Haematologica, 5(2), 22-36, 1972

Till JE, McCulloch EA, The 'f-factor' of the spleen-colony assay for hemopoietic stem cells, Series Haematologica, 5(2), 15-21, 1972

Thompson LH, Mankovitz R, Baker RM, Wright JA, Till JE, Siminovitch L, Whitmore GF, Selective and nonselective isolation of temperature-sensitive mutants of mouse L-cells and their characterization, Journal of Cellular Physiology, 78(3), 431-40, December 1971

Sutherland DJ, Till JE, McCulloch EA, Short-term cultures of mouse marrow cells separated by velocity sedimentation, Cell and Tissue Kinetics, 4(5), 479-90, September 1971

Austin PE, McCulloch EA, Till JE, Characterization of the factor in L-cell conditioned medium capable of stimulating colony formation by mouse marrow cells in culture, Journal of Cellular Physiology, 77(2), 121-34, April 1971

Iscove NN, Senn JS, Till JE, McCulloch EA, Colony formation by normal and leukemic human marrow cells in culture: effect of conditioned medium from human leukocytes, Blood, 37(1), 1-5, January 1971

Brunette DM, Till JE, A rapid method for the isolation of L-cell surface membranes using aqueous two-phase polymer system, Journal of Membrane Biology, 5, 213-24, 1971

Till JE, Wilson S, McCulloch EA, Repression of colony formation reversed by antiserum to mouse thymocytes, Science, 169(952), 1327-9, September 1970 Abstract

Thompson LH, Mankovitz R, Baker RM, Till JE, Siminovitch L, Whitmore GF, Isolation of temperature-sensitive mutants of L-cells (Eprint via: ), Proceedings of the National Academy of Sciences (USA), 66(2), 377-84, June 1970

Sutherland DJ, Till JE, McCulloch EA, A kinetic study of the genetic control of hemopoietic progenitor cells assayed in culture and in vivo, Journal of Cellular Physiology, 75(3), 267-74, June 1970

Iscove NN, Till JE, McCulloch EA, The proliferative states of mouse granulopoietic progenitor cells, Proceedings of the Society for Experimental Biology and Medicine, 134(1), 33-6, May 1970

Worton RG, McCulloch EA, Till JE, Physical separation of hemopoietic stem cells from cells forming colonies in culture, Journal of Cellular Physiology, 74(2), 171-82, October 1969

Worton RG, McCulloch EA, Till JE, Physical separation of hemopoietic stem cells differing in their capacity for self-renewal (PDF via: ), Journal of Experimental Medicine, 130(1), 91-103, July 1969

Wu AM, Siminovitch L, Till JE, McCulloch EA, Evidence for a relationship between mouse hemopoietic stem cells and cells forming colonies in culture (Eprint via: ), Proceedings of the National Academy of Sciences (USA), 59(4), 1209-15, 01 Apr 1968

Wu AM, Till JE, Siminovitch L, McCulloch EA, Cytological evidence for a relationship between normal hemotopoietic colony-forming cells and cells of the lymphoid system (PDF via: ), Journal of Experimental Medicine, 127(3), 455-64, March 1968

Senn JS, McCulloch EA, Till JE, Comparison of colony-forming ability of normal and leukaemic human marrow in cell culture, Lancet, 2(7516), 597-8, September 1967

Wu AM, Till JE, Siminovitch L, McCulloch EA, A cytological study of the capacity for differentiation of normal hemopoietic colony-forming cells, Journal of Cellular Physiology, 69(2), 177-84, April 1967

Fowler JH, Wu AM, Till JE, McCulloch EA, Siminovitch L, The cellular composition of hemopoietic spleen colonies, Journal of Cellular Physiology, 69, 65-72, 1967

Williams JF, Till JE, Formation of lung colonies by polyoma-transformed rat embryo cells, Journal of the National Cancer Institute, 37(2), 177-84, August 1966

Kennedy JC, Till JE, Siminovitch L, McCulloch EA, The proliferative capacity of antigen-sensitive precursors of hemolytic plaque-forming cells, Journal of Immunology, 96(6), 973-80, June 1966

Thompson MW, McCulloch EA, Siminovitch L, Till JE, The cellular basis for the defect in haemopoiesis in flexed-tailed mice. I. The nature and persistance of the defect, British Journal of Haematology, 12(2), 152-60, March 1966

Kennedy JC, Siminovitch L, Till JE, McCulloch EA, A transplantation assay for mouse cells responsive to antigenic stimulation by sheep erythrocytes, Proceedings of the Society for Experimental Biology and Medicine, 120(3), 868-73, December 1965

McCulloch EA, Siminovitch L, Till JE, Russell ES, Bernstein SE, The cellular basis of the genetically determined hemopoietic defect in anemic mice of genotype Sl-Sld, Blood, 26(4), 399-410, October 1965

Becker AJ, McCulloch EA, Siminovitch L, The effect of differing demands for blood cell production on DNA synthesis by hemopoietic colony-forming cells of mice, Blood, 26, 296-308, 1965

Bruchovsky N, Owen A, Becker AJ, Till JE, Effect of vinblastine on the proliferative capacity of L cells and their progress through the division cycle, Cancer Research, 25, 1232-7, 1965

McCulloch EA, Siminovitch L, Till JE, Spleen-colony formation in anemic mice of genotype WWv (PDF via: ), Science, 144, 844-6, 01 Jan 1964

Whitmore GF, Till JE, Quantitation of cellular radiobiological responses, Annual Review of Nuclear Science, 14, 347-74, 1964

Till JE, McCulloch EA, Siminovitch L, A stochastic model of stem cell proliferation, based on the growth of spleen colony-forming cells (Eprint via: ), Proceedings of the National Academy of Sciences (USA), 51(1), 29-36, January 1964

Siminovitch L, McCulloch EA, Till JE, The distribution of colony-forming cells among spleen colonies (PDF via: ), Journal of Cellular and Comparative Physiology, 62(3), 327-36, 01 Dec 1963

McCulloch EA, Till JE, Repression of colony-forming ability of C57BL hematopoietic cells transplanted into non-isologous hosts, Journal of Cellular and Comparative Physiology, 61(3), 301-8, June 1963

Becker AJ, McCulloch EA, Till JE, Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells (PDFs via: and , Nature, 197(4866), 452-4, 02 Feb 1963

McCulloch EA, Till JE, The sensitivity of cells from normal mouse bone marrow to gamma radiation in vitro and in vivo, Radiation Research, 16(6), 822-32, June 1962

Till JE, McCulloch EA, A direct measurement of the radiation sensitivity of normal mouse bone marrow cells (PDF via: ), Radiation Research, 14(2), 213-22, Feb 1961

McCulloch EA, Till JE, The radiation sensitivity of normal mouse bone marrow cells, determined by quantitative marrow transplantation into irradiated mice (PDF via: ), Radiation Research, 13(1), 115-25, Jul 1960

Stanners CP, Till JE, DNA synthesis in individual L-strain mouse cells, Biochimica et Biophysica Acta, 37, 406-19, 1960

Till JE, Pollard EC, Effects of ionizing radiation on cross-reactivation of T1 bacteriophage, Radiation Research, 8, 344-60, 1958

Gwatkin RBL, Till JE, Whitmore GF, Siminovitch L, Graham AF, Multiplication of animal cells in suspension measured by colony counts (Eprint via: ), Proceedings of the National Academy of Sciences (USA), 43, 451-7, 01 Jan 1957

Cormack DV, Till JE, Whitmore GF, Johns HE, Measurement of continuous x-ray spectra with a scintillation spectrometer, British Journal of Radiology, 28, 605-9, 1955

Johns HE, Till JE, Cormack DV, Electron energy distributions produced in water by gamma-rays, Nucleonics, 12, 40-6, 1954