Chercheurs

Médecine / SELKOE, DENNIS J.

dselkoe

Position

Vincent and Stella Coates Professor of Neurologic Diseases,
Harvard Medical School, Boston, MA, United States.

Member of several editorial committees of scientific journals dealing with neurological topics, such as the "Annual Review of Neuroscience" and "Neuron".

Thèmes de recherche

Biochemistry and molecular and cell biology of cerebral degeneration during aging of the mammalian brain, particularly in Alzheimer’s disease (AD).

Prix et récompenses

Dr A.H. Heineken Prize for Medicine 2002 "for his invaluable contribution to the development of the molecular study of diseases of the brain, in particular Alzheimer’s disease".

Publications

Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Selkoe DJ (1999) Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and g -secretase activity. Nature 398: 513-517.

Kimberly WT, Zheng JB, Guenette S, Selkoe DJ. The intracellular domain of the ß-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a Notch-like manner. J Biol Chem, 2001, 276: 40288-40292.

Shimura H, Schlossmacher MG, Hattori N, Frosch MP, Trockenbacher A, Schneider R, Mizuno Y, Kosik KS, Selkoe DJ. Ubiquitination of a new form of a -synuclein by parkin from human brain: Implications for Parkinson’s disease. Science, 2001; 293: 263-269.

Selkoe DJ. Alzheimer’s Disease: Genes, Proteins and Therapy. Physiol Rev, 2001, 81: 741-766.

Esler W, Kimberly WT, Ostaszewski BL, Diehl T, Selkoe DJ, Wolfe MS. Activity dependent isolation of the presenilin/g -secretase complex reveals nicastrin and a g substrate. Proc Natl Acad Sci USA, 2002, 99: 2720-2725.

Walsh DM, Klyubin I, Fadeeva J, Cullen WK, Anwyl R, Wolfe MS, Rowan JH, Selkoe DJ. Naturally secreted oligomers of the Alzheimer amyloid ß-protein potently inhibit hippocampal long-term potentiation in vivo. Nature, 2002, 416: 535-539.