Chercheurs

Sciences de la Vie / EDELSTEIN, STUART J.

Stuart.Edelstein

Position

Professor at the Department of Biochemistry, University of Geneva, Geneva, Switzerland.

Thèmes de recherche

- cooperative oxygen binding and the structure of hemoglobin, especially the helical fibers of the sickling mutant, hemoglobin S (beta 6 Glu to Val),
- the structure and function of tubulin, especially from yeast, as well as microtubule associated proteins,
- detailed modeling of the kinetics of ligand-gated channels. An allosteric-type mechanistic model incorporating linear free energy relations to describe the effects of ligand binding on interconversions between conformations has been developed and applied principally to single channel data of the nicotinic acetylcholine receptor and certain myasthenic mutants.

Prix et récompenses

Publications

Changeux, J.-P., et Edelstein, S. J. (2001). Allosteric mechanisms in normal et pathological nicotinic acetylcholine receptors. Curr. Opin. Neurobiol. 11, 369-77.

Palanche, T., Ilien, B., Zoffmann, S., Reck, M. P., Bucher, B., Edelstein, S. J., et Galzi, J. L. (2001). The Neurokinin A Receptor Activates Calcium et cAMP Responses through Distinct Conformational States. J. Biol. Chem. 276, 34853-34861.

Martinez, K. L., Corringer, P. J., Edelstein, S. J., Changeux, J. P., and Merola, F. (2000). Structural Differences in the Two Agonist Binding Sites of the Torpedo Nicotinic Acetylcholine Receptor Revealed by Time-Resolved Fluorescence Spectroscopy. Biochemistry 39:6979-6990.

Changeux, J.-P. and Edelstein, S. J. (1998) Allosteric Receptors after 30 Years. Neuron 21, 959-980.

Edelstein, S.J. and Changeux, J.-P. (1998). Allosteric Transitions of the Acetylcholine Receptor. Adv.Prot.Chem. 51, 121-184.

Changeux, J.-P., Bertret, D., Corringer, P. J., Dehaene, S., Edelstein, S., Lena, C., Le Novere, N., Marubio, L., Picciotto, M., et Zoli, M. (1998). Brain nicotinic receptors: structure and regulation, role in learning et reinforcement. Brain Res. Brain Res. Rev. 26, 198-216.