Chercheurs

Chimie / NAKANISHI, KOJI

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Position

Centennial Professor of Chemistry,
Department of Chemistry,
Columbia University
New York, U.S.A.

Thèmes de recherche

Nakanishi's recent research concentrates on the interaction of light with the molecules responsible for vision. These studies are likely to accelerate the development of a treatment for macular degeneration, which affects many elderly people and leads to the loss of sight.

Prix et récompenses

1999 Prestigious Japanese Prize
2003 King Faisal Science Prize

In 1996 the American Chemical Society and the Chemical Society of Japan paid tribute to his many outstanding contributions when they announced the creation of the Nakanishi Prize to recognize "significant work that extends chemical and spectroscopic methods to the study of important biological phenomena."

Publications

"Broad-Spectrum Antimicrobial Activity of Hemoglobin," C.A. Parish, H. Jiang, Y. Tokiwa, N. Berova, K. Nakanishi, D. McCabe, W. Zuckerman, M.M. Xia, and J.E. Gabay, Bioorganic & Medicinal Chem., 9, 377382 (2001)

"Conformational Flexibility of Ouabain and Its Biological Implication: Observations with Ouabain 1,5,19- and 1,11,19-Phosphates," A. Kawamura, L.M. Abrell, F. Maggiali, N. Berova, K. Nakanishi, J. Labutti, G.T.J. Haupert, and J.M. Hamlyn, Biochemistry, 40 (2001)

"Chiral Recognition by CD-Sensitive Dimeric Zinc Porphyrin Host. 1. Chiroptical Protocol for Absolute Configurational Assignments of Monoalcohols and Primary Monoamines," T. Kurtan, N. Nesnas, Y.-Q. Li, X. Huang, K. Nakanishi, and N. Berova, J. Am. Chem. Soc., 123, 25, 59625973 (2001)

"Chiral Recognition by CD-Sensitive Dimeric Zinc Porphyrin Host. 2. Structural Studies of Host-Guest Complexes with Chiral Alcohol and Monoamine Conjugates," T. Kurtan, N. Nesnas, F.E. Koehn, Y.-Q. Li, K. Nakanishi, and N. Berova, J. Am. Chem. Soc., 123, 25, 59745982 (2001)

"Fluorescent Pigments of the Retinal Pigment Epithelium and Age-Related Macular Degeneration," S. Ben-Shabat, C.A. Parish, M. Hashimoto, J. Liu, K. Nakanishi, and J.R. Sparrow, Bioorganic & Medicinal Chem., 11, 15331540 (2001)

"Porphyrins and Metalloporphyrins: Versatile Circular Dichroic Reporter Groups for Structural Studies," S. Huang, K. Nakanishi, and N. Berova, Chirality, 12, 237255 (2000)

"Relative and Absolute Configurations of Ganefromycin å," T. Andersson, N. Berova, K. Nakanishi, and G.T. Carter, Organic Letters, 2, 919920 (2000) "Movement of Retinal Along the Visual Transduction Path," B. Borhan, M.L. Souto, H. Imai, Y. Shichida, and K. Nakanishi, Science, 288, 22092212 (2000)

"The Biosynthesis of A2E, a Fluorophore of Aging Retina, Involves the Formation of the Precursor, A2-PE, in the Photoreceptor Outer Segment Membrane," J. Liu, Y. Itagaki, S. Ben-Shabat, K. Nakanishi, and J.R. Sparrow, J Biol. Chem., 275, 2935429360 (2000)

"Recent Bioorganic on Rhodopsin and Visual Transduction," K. Nakanishi, Chem. Pharm. Bull., 48, 10, 13991409 (2000)