Chercheurs

Médecine / MURAD, FERID

Ferid.Murad

Position

Pharmacologist,

The John S. Dunn Distinguished Chair
Physiology and Medicine
Director, Institute of Molecular Medicine

Professor and Chairman
Integrative Biology & Pharmacology
Regental Professor

Department of Integrative Biology and Pharmacology,
University of Texas Medical School at Houston,
Houston, TX, USA.

Thèmes de recherche

Nitric Oxide and Molecular Signaling.

His research focuses on the formation, metabolism and function of nitric oxide and cyclic GMP as they participate in various cellular signaling processes. Nitric oxide is formed from L-arginine by one of several isoforms of nitric oxide synthase. Nitric oxide is also formed from a number of prodrugs or nitrovasodilators such as nitroglycerin and nitroprusside. There are few biological processes that are not regulated by nitric oxide. The formation of nitric oxide and/or cyclic GMP by many hormones, toxins, cytokines, growth factors and drugs can explain their mechanisms of action.

Prix et récompenses

Nobel Prize in Medicine or Physiology (1998), along with Robert F. Furchgott and Louis J. Ignarro, for the discovery that nitric oxide (NO) acts as a signaling molecule in the cardiovascular system.

Albert Lasker Basic Medical Research Award (1996)

Ciba Award Recipient (1988)

Publications

Bian K. and Murad F. Diversity of endotoxin-induced nitrotyrosine formation in macrophage-endothelium-rich organs. Free Radic Biol Med. 2001 Aug 15;31(4):421-9.

Murad, F. Discovery of some of the biological effects of nitric oxide and its role in cell signaling. Biosci Rep 1999 Jun;19(3):133-54.

Murad, F.: Signal transduction using nitric oxide and cyclic guanosine monophosphate. JAMA, 276, 1189-1192, 1996.