Chercheurs

Chimie / NEGISHI, EI-ICHI

negishi

Position

Herbert C. Brown Distinguished Professor of Organic Chemistry at Purdue University, Department of Chemistry, USA.

In December 2010, he received the Nobel Prize in Chemistry for developing metal-based reactions called palladium-catalyzed cross-coupling, that allow for easy and efficient synthesis of complex organic compounds.

Thèmes de recherche

Professor Ei-ichi Negishi is a pioneer in developing metal-based reactions called palladium-catalyzed cross-coupling, that allow for easy and efficient synthesis of complex organic compounds.

By creating a more precise method for coupling two different (or same) carbon groups, Dr. Negishi created a powerful tool for synthesizing a wide range of useful chemicals used in medicine, agriculture, and electronics.

He shares the 2010 Nobel Prize with Richard Heck of the University of Delaware and Akira Suzuki from Hokkaido University in Sapporo, Japan. (Both Negishi and Suzuki studied at Purdue under Professor Herbert C. Brown, a 1979 Nobel Laureate.)

Their methods are now widely used in industry and research in a variety of applications including: pharmaceutical antibiotics that work on drug resistant bacteria, agricultural chemicals that protect crops from fungi, and electronic light-emitting diodes used in the production of extremely thin monitors.

Prix et récompenses

Foreign Associate of the National Academy of Sciences, 2014
American Academy of Arts & Sciences, 2011
Order of the Griffin, 2011
Sagamore of the Wabash, 2011
ACS Award for Creative Work in Synthetic Organic Chemistry , 2010
Nobel Prize in Chemistry, 2010
The Order of Culture, Japan, 2010
Invited Lectureship, 4th Mitsui International Catalysis Symposium (MICS-4), Kisarazu, Japan, 2009
Gold Medal of Charles University, Prague, Czech Republic , 2007
Yamada-Koga Prize , 2007
Sigma Xi Award, Purdue University , 2003
Sir Edward Frankland Prize Lectureship , 2000
Alexander von Humboldt Senior Researcher Award, 1998-2000
American Chemical Society Award for Organometallic Chemistry, 1998
Herbert N. McCoy Award, 1998
Chemical Society of Japan Award, 1997
A. R. Day Award (ACS Philadelphia Section award), 1996
Guggenheim Fellowship, 1987
Assistant and Associate Professor, Syracuse University, 1972-1979
Harrison Fellowship at University of Pennsylvania, 1962-63
Fulbright-Smith-Mund Fellowship, 1960-61

Publications

Wang, C.; Tobrman, T.; Xu, E.; Negishi, E., Arylethyne Bromoboration-Negishi Coupling Route to E- or Z-Aryl-Substituted Trisubstituted Alkenes of ?98% Isomeric Purity. New Horizon in the Highly Selective Synthesis of Trisubstituted Alkenes. Adv. Synth. Catal. 2010 , 352, 627-631.

Negishi, E.; Wang, G.; Rao, H.; Xu, Z, Alkyne Elementometalation–Pd-Catalyzed Cross-Coupling. Towards Synthesis of Any Alkenes in High Yields, Efficiently, Selectively, Economically, and Safely–“Green” Way. J. Org. Chem 2010 , 75, 3151-3182.

Pitsinos, E.; Athinaios, N.; Xu, Z.; Wang, G.; Negishi, E., Total Synthesis of (+)-Scyphostatin Featuring An Enantioselective and Highly Efficient Route to the Side-Chain via Zr-Catalyzed Asymmetric Carboalumination of Alkenes (ZACA). Chem. Commun. 2010 , 46, 2200-2202.