Chercheurs

Chimie / COOKS, R. GRAHAM

cooks

Position

Henry Bohn Hass Distinguished Professor at the Department of Chemistry, Purdue University, West Lafayette, USA.

Head of the Aston Labs research group.

Thèmes de recherche

Analytical Chemistry

Mass spectrometry is of interest to his group, including fundamental phenomena, instrumentation and analytical applications. They study collisions of ions in the gas phase and at surfaces. The latter experiment aims at new methods of molecular surface analysis. In addition to reactive scattering, soft-landing of ions at surfaces has recently been discovered. Development of the Paul ion trap and the construction of miniature ion trap arrays is the focus of an instrumentation effort, the practical aims of which include in-situ on-line analysis. Ion motion simulations and laser tomography experiments facilitate the ion trap effort. They are currently employing ion/molecule reactions to recognize functional groups in polyfunctional compounds. Fundamental thermochemical properties such as proton affinities are being measured using the kinetic method, which was developed from our earlier interest in ion structure and fragmentation mechanism. Their interests also include ion mobilities and other physical properties of biological molecules, trace environmental analysis and atmospherically relevant ion/molecule reactions. Several new types of mass spectrometers have been constructed in Prof. Cooks' laboratory, including hybrid sector/quadrupole instruments and advanced ion trap instruments. His group has made significant contributions to the development of desorption ionization and tandem mass spectrometry as methods of analysis of complex mixtures.

Prix et récompenses

1981: Fulbright Fellow, University of Warwick
1983: Purdue Cancer Research Award, Indiana Ion Club. Listed as one of the four most cited analytical chemists by Current Contents
1984: ACS Analytical Division's Chemical Instrumentation Award
1985: Thomson Medal for International Service to Mass Spectrometry
1986: Purdue Sigma Xi Faculty Research Award
1987: Honorary Member of the Chinese Mass Spectrometry Society. Adjunct Professor at the Beijing Institute of Technology
1990: Herbert Newdy McCoy Award
1990: 1995: NSF Special Creativity Award
1991: Frank H. Field & Joe Franklin Award, (ACS Award for Mass Spectrometry)
1997: Fisher Award (ACS Award for Analytical Chemistry)
1999: D. Sc. (Honoris Causa), University of Natal (South Africa)
1999: Honorary Life Member of the British Mass Spectrometry Society
2000: Pittsburgh Spectroscopy Award from the Spectroscopy Society of Pittsburgh, PITTCON
2000: ALA Achievement Award from the Association for Laboratory Automation
2001: Honor issue, International Journal of Mass Spectrometry
2001: Highly Cited Chemist, 1981-1999, 1of 98 chemists, ISI Institute for Scientific Information
2002: Honorary Professor, Jilin University, Chang Chun, China
2003- : Honorary Professor, Changchun Institute of Applied Chemistry
2004-2007: Guest Professor, Chemistry Department, Tsinghua University, Beijing,China
2005: Outstanding Faculty Commercialization Award, Purdue University
2005: Alexander M. Cruickshank Lecturer, Gordon Conferences

Publications

Justin M. Wiseman, Zoltan Takats, Bogdan Gologan, V.J. Davisson, R. Graham Cooks, "Direct Characterization of Enzyme-Substrate Complexes using Electrosonic Spray Mass Spectrometry" , Angewandte Chemie International Edition , 2005 , 44(6), 913-916, doi: 10.1002/anie.200461672

Alexander S. Misharin, Brian C. Laughlin, Andrey Vilkov, Zoltan Takats, Zheng Ouyang, and R. Graham Cooks, "High Throughput Mass Spectrometry using Atmospheric Pressure Ionization in a Cylindrical Ion Trap Array" , Analytical Chemistry , 2005 , 77, 459-470, doi: 10.1021/ac048983w

Sergio C. Nanita and R. Graham Cooks, "Negatively-Charged Halide Adducts of Homochiral Serine Octamers" , Journal of Physical Chemistry B , 2005 , 109 (10), 4748-4753, doi: 10.1021/jp046653+

Ismael Cotte-Rodriquez, Eric Handberg, Robert J. Noll, David P. A. Kilgour and R. Graham Cooks, "Improved detection of low vapor pressure compounds in air by serial combination of single-sided membrane introduction with fiber introduction mass spectrometry (SS-MIMS-FIMS)" , Analyst , 2005 , 130, 679-686, doi: 10.1039/b417791f

Guangxiang Wu, R. Graham Cooks and Zheng Ouyang, "Geometry Optimization for the Cylindrical Ion Trap: Field Calculations, Simulations and Experiments" , International Journal of Mass Spectrometry , 2005 , 241 (2-3), 119-132, doi: 10.1016/j.ijms.2004.12.004

Zoltan Takats, Ismael Cotte-Rodriguez, Nari Talaty, Huanwen Chen and R. Graham Cooks, "Direct, trace level detection of explosives on ambient surfaces by desorption electrospray ionization mass spectrometry" , Chemical Communications , 2005 , 15, 1950-1952, doi: 10.1039/b418697d

Alvarez, Jormarie; Cooks, R. Graham; Barlow, S. E.; Gaspar, Daniel J.; Futrell, Jean H.; Laskin, Julia, "Preparation and in situ characterization of surfaces using soft landing in a Fourier transform ion cyclotron resonance mass spectrometer" , Analytical Chemistry , 2005 , 77 (11), 3452-3460, doi: 10.1021/ac0481349

Igor A. Popov, Hao Chen, Oleg N. Kharybin, Eugene N. Nikolaev and R. Graham Cooks, "Detection of Explosives on Solid Surfaces by Thermal Desorption and Ambient Ion/Molecule Reactions" , Chemical Communications , 2005 , 1953-1955, doi: 10.1039/b419291e

Ester Marotta, R. Graham Cooks and Cristina Paradisi, "Novel CFCs-substitutes recommended by EPA (hydrofluorocarbon-245fa and hydrofluoroether-7100): ion chemistry in air plasma and reactions with atmospheric ions" , Analyst , 2005 , 16, 1081-1092, doi: 10.1016/j.jasms.2005.02.021

Bogdan Gologan, Jason R. Green, Jormarie Alvarez, Julia Laskin and R. Graham Cooks, "Ion/Surface Reactions and Ion Soft-Landing" , Physical Chemistry Chemical Physics , 2005 , 7, 1490doi: 10.1039/b418056a

Brian C. Laughlin, Christopher C. Mulligan, R. Graham Cooks, "Atmospheric Pressure Ionization in a Miniature Mass Spectrometer" , Analytical Chemistry , 2005 , 77, 2928-2939, doi: 10.1021/ac0481708

Yang, Pengxiang; Cooks, R. Graham; Ouyang, Zheng; Hawkridge, Adam M.; Muddiman, David C., "Gentle Protein Ionization Assisted by High-Velocity Gas Flow" , Analytical Chemistry , 2005 , 77(19), 6174-6183, doi: 10.1021/ac050711l

Qizhi Hu, Robert J. Noll, Hongyan Li, Alexander Makarov, Mark Hardman, R. Graham Cooks, "The Orbitrap: a new mass spectrometer" , Journal of Mass Spectrometry , 2005 , 40, 430-443, doi: 10.1002/jms.856

Kanik, L. W. Beegle, P. V. Johnson, D. T. Young, B. C. Laughlin and R. Graham Cooks, "Mass spectrometers and other analytical separation devices for planetary applications: A Critical Review" , Review of Scientific Instruments , 2005 , submitted,

Wu, Lianming; Cooks, R. Graham, "Chiral and isomeric analysis by electrospray ionization and sonic spray ionization using the fixed-ligand kinetic method" , European Journal of Mass Spectrometry , 2005 , 11(2), 231-242, doi: 10.1255/ejms.749

Hao Chen, R. Graham Cooks, Eduardo C. Meurer and Marcos N. Eberlin, "Hydrogen/Chlorine Exchange Reactions of Gaseous Carbanions" , Journal of the American Society of Mass Spectrometry , 2005 , 16(12), 2045-2051, dx.doi: 10.1016/j.jasms.2005.08.012

Huanwen Chen, Ruifeng Xu, Hao Chen, R. Graham Cooks and Zheng Ouyang, "Ion/Molecule Reactions in a Miniature RIT Mass Spectrometer" , Journal of Mass Spectrometry , 2005 , 40, 11, 1403-1411, doi: 10.1002/jms.924

Hao Chen, Dina R. Justes and R. Graham Cooks, "Proton Affinities of N- Heterocyclic Carbene Super Bases" , Organic Letters , 2005 , 7, 3949-3952, doi: 10.1021/ol0514247

Huanwen Chen, Nari N. Talaty, Zoltan Takats, and R. Graham Cooks, "Desorption Electrospray Ionization Mass Spectrometry for High-Throughput Analysis of Pharmaceutical Samples in the Ambient Environment" , Analytical Chemistry , 2005 , 77(21), 6915-6927, doi: 10.1021/ac050989d

Ismael Cotte-Rodriguez, Zoltan Takats, Nari Talaty, Huanwen Chen, and R. Graham Cooks, "Desorption Electrospray Ionization of Explosives on Surfaces: Sensitivity and Selectivity Enhancement by Reactive Desorption Electrospray Ionization" , Analytical Chemistry , 2005 , 77(21), 6755-6764, doi: 10.1021/ac050995+

Nari Talaty, Zoltan Takats, R. Graham Cooks, "Rapid In-Situ Detection of Alkaloids in Plant Tissue under Ambient Conditions using Desorption Electrospray Ionization" , Analyst , 2005 , (12), 1624-1633, doi: 10.1039/b511161g

Justin M. Wiseman, Satu M. Puolitaival, Zoltan Takats, R. Graham Cooks, Richard M. Caprioli, "Mass Spectrometric Profiling of Intact Biological Tissues by using Desorption Electrospray Ionization" , Angewandte Chemie International Edition , 2005 , 44(43), 7094-7097, doi: 10.1002/anie.200502362

Yishu Song, Hao Chen and R. Graham Cooks, "Reactivity of Acetonyl Anion with Nitroaromatics: An Atmospheric Pressure Chemical Ionization Study" , Rapid Communications in Mass Spectrometry , 2005 , 19, 23, 3493-3499, doi: 10.1002/rcm.2206

Takats, Zoltan; Wiseman, Justin M.; Cooks, R. Graham, "Ambient mass spectrometry using desorption electrospray ionization (DESI): Instrumentation, mechanisms and applications in forensics, chemistry, and biology" , Journal of Mass Spectrometry , 2005 , 40(10), 1261-1275, doi: 10.1002/jms.922

Sunnie Myung, Justin M. Wiseman, Stephen J. Valentine, Zoltán Takáts, R. Graham Cooks, and David E. Clemmer, "Coupling Desorption Electrospray Ionization (DESI) with Ion Mobility/Mass Spectrometry for Analysis of Protein Structure: Evidence for Desorption of Folded and Denatured States" , Journal of Physical Chemistry B , 2006 , 110(10), 5045-5051, doi: 10.1021/jp052663e

Chao Zhang, Huanwen Chen, Andrew J. Guymon, Guangxiang Wu, R. Graham Cooks and Zheng Ouyang, "Instrumentation and Methods for Ion and Reaction Monitoring using a Non-Scanning Rectilinear Ion Trap" , International Journal of Mass Spectrometry , 2006 , 255-256, 1-10, doi: 10.1016/j.ijms.2005.10.013

Qizhi Hu, Alexander A. Makarov, R. Graham Cooks and Robert J. Noll, "Resonant AC Dipolar Excitation for Ion Motion Control in the Orbitrap Mass Analyzer" , Journal of Physical Chemistry A , 2006 , 110(8), 2682-2689, doi: 10.1021/jp054485v

Amy M. Tabert, Michael P. Goodwin, R. Graham Cooks, "Co-occurrence of Boundary and Resonance Ejection in a Multiplexed Rectilinear Ion Trap Mass Spectrometer" , Journal of the American Society of Mass Spectrometry , 2006 , 17, 56-59, doi: 10.1016/j.jasms.2005.09.005

Kauppila, T. J; Wiseman, J. M.; Ketola, R. A.; Kotiaho, T. Cooks, R. G.; Kostiainen, R., "Desorption Electrospray Ionization Mass Spectrometry for the Analysis of Pharmaceuticals and Metabolites" , Rapid Communications in Mass Spectrometry , 2006 , 20(3), 387-392, doi: 10.1002/rcm.2304

Huanwen Chen, Zhengzheng Pan, Nari N. Talaty, R. Graham Cooks and Daniel Raftery, "Combining Desorption Electrospray Ionization Mass Spectrometry and Nuclear Magnetic Resonance for Differential Metabolomics without Sample Separation" , Rapid Communications in Mass Spectrometry , 2006 , 20, 10, 1577-1584, doi: 10.1002/rcm.2474

Marcela Nefliu, Andre Venter, R. Graham Cooks, "Desorption electrospray ionization and electrosonic spray ionization for solid- and solution-phase analysis of industrial polymers" , Chemical Communications , 2006 , 888-890, doi: 10.1039/b514057a

Cooks, R. G.; Chen, Hao; Eberlin, M. N.; Zheng, X.; Tao, W. A., "Polar Acetalization and Transacetalization in the Gas Phase: The Eberlin Reaction" , Chemical Reviews , 2006 , 106(1), 188-211, doi: 10.1021/cr0400921

Nanita, Sergio C.; Cooks, R. Graham, "Serine Octamers: Cluster Formation, Reactions, and Implications for Biomolecule Homochirality" , Angewandte Chemie International Edition , 2006 , 45(4), 554-569, doi: 10.1002/anie.200501328

Ismael Cotte-Rodriguez, Dina R. Justes, Sergio C. Nanita, Robert J. Noll, Christopher C. Mulligan, Nathaniel L. Sanders, R. Graham Cooks, "Analysis of gaseous toxic industrial compounds and chemical warfare agent simulants by atmospheric pressure ionization mass spectrometry" , Analyst , 2006 , 131, 579-589, doi: 10.1039/b513605a

Qingyu Song, Sameer Kothari, Michael A. Senko, Jae C. Schwartz, Jonathan W. Amy, George C. Stafford, R. Graham Cooks, and Zheng Ouyang, "Rectilinear Ion Trap Mass Spectrometer with Atmospheric Pressure Interface and Electrospray Ionization Source" , Analytical Chemistry , 2006 , 78(3), 718-725, doi: 10.1021/ac0512709

Ismael Cotte-Rodriguez, Hao Chen, R. Graham Cooks, "Rapid trace detection of triacetone triperoxide (TATP) by complexation reactions during desorption electrospray ionization" , Chemical Communications , 2006 , 953-955, doi: 10.1039/b515122h

Hao Chen, Ismael Cotte-Rodríguez, R. Graham Cooks, "cis-Diol functional group recognition by reactive desorption electrospray ionization (DESI)" , Chemical Communications , 2006 , 6, 597-599, doi: 10.1039/b516448f

Christopher C. Mulligan, Dina R. Justes, Robert. J. Noll, Nathaniel L. Sanders, Brian C. Laughlin and R. Graham Cooks, "Direct Monitoring of Gaseous Toxic Compounds in Air Using a Portable Mass Spectrometer" , Analyst , 2006 , 131, 556-567, doi: 10.1039/b517541k

Bogdan Gologan, Justin M. Wiseman and R. Graham Cooks, "Ion soft landing: Instrumentation and Phenomena" , 2006 , C. Lifshitz and J. Laskin, Eds., New York: Wiley, 2006., doi:10.1002/047005042

Yishu Song, Guangxiang Wu, Qingyu Song, Wolfgang R. Plass, R. Graham Cooks and Zheng Ouyang, "Novel Linear Ion Trap Mass Analyzer Composed of Four Planar Electrodes" , Journal of the American Society of Mass Spectrometry , 2006 , 17(4), 631-639, doi: 10.1016/j.jasms.2005.12.014

Marcela Nefliu, Colin Moore, and R. Graham Cooks, "Enhanced Desorption Ionization using Oxidizing Electrosprays" , Journal of the American Society of Mass Spectrometry , 2006 , 17(8), 1091doi: 10.1016/j.jasms.2006.04.021

Meng Yu, Miriam Fico, Sameer Kothari, Zheng Ouyang and William J. Chappell, "Polymer-Based Ion Trap Chemical Sensor" , IEEE Sensors , 2006 , 6, 6, 1429-1434, doi: 10.1109/JSEN.2006.883853

Christopher C. Mulligan, Nari N. Talaty and R. Graham Cooks, "Desorption Electrospray Ionization with a Portable Mass Spectrometer: In-situ Analysis of Ambient Surfaces" , Chemical Communications , 2006 , 1709-1711, doi: 10.1039/b517357d

Amy M. Tabert, Michael P. Goodwin, Jason S. Duncan, Charles D. Fico, and R. Graham Cooks, "Multiplexed Rectilinear Ion Trap Mass Spectrometer for High-Throughput Analysis" , Analytical Chemistry , 2006 , 78(14), 4830-4838, doi: 10.1021/ac060149e

Yishu Song and R. Graham Cooks, "Atmospheric Pressure Ion/Molecule Reactions for the Selective Detection of Nitroaromatic Explosives using Acetonitrile and Air as Reagents" , Rapid Communications in Mass Spectrometry , 2006 , 20, 20, 3130-3138, doi: 10.1002/rcm.2714

Brandy L. Young, Lianming Wu, R. G. Cooks, "Mass Spectral Methods of Chiral Analysis" , 2006 , ed.: Kenneth W. Busch; M. A. Busch,
Hao Chen, Zheng Ouyang, R. Graham Cooks, "Thermal Production and Reactions of Organic Ions at Atmospheric Pressure" , Angewandte Chemie International Edition , 2006 , 45, 3656-3660, doi: 10.1002/anie.200600660

Rodinei Augusti, Hao Chen, Livia Schiavinato Eberlin, Marcela Nefliu and R. Graham Cooks, "Atmospheric pressure Eberlin transacetalization reactions in the heterogeneous liquid/gas phase" , International Journal of Mass Spectrometry , 2006 , 253, 281-287, doi: 10.1016/j.ijms.2006.05.005

Tiina J. Kauppila, Nari Talaty, Piia K. Salo, Tapio Kotiaho, Risto Kostiainen and R. Graham Cooks, "New Surfaces for Desorption Electrospray- Mass Spectrometry: Porous Silicon and Ultra-Thin Layer Chromatography Plates" , Rapid Communications in Mass Spectrometry , 2006 , 20, 14, 2143-2150, doi: 10.1002/rcm.2566

R. Graham Cooks, Zheng Ouyang, Zoltan Takats, Justin M. Wiseman, "Ambient Mass Spectrometry" , Science , 2006 , 311(5767), 1566-1570, doi: 10.1126/science.1119426

Guangxiang Wu, R. Graham Cooks, Zheng Ouyang, Meng Yu, William J. Chappell and Wolfgang R. Plass, "Ion Trajectory Simulation for Electrode Configurations with Arbitrary Geometries" , Journal of the American Society of Mass Spectrometry , 2006 , 17, 9, 1216-1228, doi:10.1016/j.jasms.2006.05.004

Guangxiang Wu, Robert J. Noll, Wolfgang R. Plass, Qizhi Hu, Richard H. Perry, and R. Graham Cooks, "Ion Trajectory Simulations of Axial AC Dipolar Excitation in the Orbitrap" , International Journal of Mass Spectrometry , 2006 , 254, 1-2, 53-62, doi: 10.1016/j.ijms.2006.05.007

Huanwen Chen, Andre Venter and R. Graham Cooks, "Extractive electrospray ionization for direct analysis of undiluted urine, milk and other complex mixtures without sample preparation" , Chemical Communications , 2006 , 2042-2044, doi : 10.1039/b602614a

Justin M. Wiseman, Demian Ifa, Zoltan Takats and R. Graham Cooks, "Desorption electrospray ionization: proteomics studies by a method that bridges ESI and MALDI" , Proteomics- Methods Express, Scion Publishing Limited, Bloxham, UK , 2006 ,

Ismael Cotte-Rodriguez and R. Graham Cooks, "Non-Proximate Detection of Explosives and Chemical Warfare Agent Simulants by Desorption Electrospray Ionization Mass Spectrometry" , Chemical Communications , 2006 , 28, 2968-2970, doi : 10.1039/b606020j

A.Venter, S.K. Poehlein, D.R. Ifa, A. Chin, D. Ellison, and R.G. Cooks, "Desorption electrospray ionization mass spectrometry study of aging products of diphenylamine stabilizer in double base propellants, Propellants, Explosives" , Propellants, Explosives, Pyrotechnics , 2006 , 31, 6, 472-476, doi:10.1002/prep.200600064

Pengxiang Yang, Ruifeng Xu, Sergio C. Nanita, and R. Graham Cooks, "Thermal Formation of Homochiral Serine Clusters and Implications for the Origin of Homochirality" , Journal of the American Chemical Society , 2006 , 128(51), 17074-17086, doi: 10.1021/ja064617d

Justin M. Wiseman, Demian R. Ifa, Qingyu Song, R. Graham Cooks, "Tissue Imaging at Atmospheric Pressure using Desorption Electrospray Ionization(DESI) Mass Spectrometry" , Angewandte Chemie International Edition , 2006 , 45, 43, 7188-7192, doi: 10.1002/anie.200602449

Qizhi Hu, Nari Talaty, Robert J. Noll and R. Graham Cooks, "Desorption Electrospray Ionization (DESI) using an Orbitrap Mass Spectrometer: Exact Mass Measurements on Drugs and Peptides" , Rapid Communications in Mass Spectrometry , 2006 , 20, 22, 3403doi: 10.1002/rcm.2757

Liang Gao, Qingyu Song, Garth E. Patterson, R. Graham Cooks, and Zheng Ouyang, "Handheld Rectilinear Ion Trap Mass Spectrometer" , Analytical Chemistry , 2006 , 78(17) , 5994-6002, doi: 10.1021/ac061144k

A.Venter, P.E.Sojka, R.G.Cooks, "Droplet dynamics and ionization mechanisms in desorption electrospray ionization" , Analytical Chemistry , 2006 , 78(24), 8549-8555, doi: 10.1021/ac0615807

Regina Sparrapan, Livia S. Eberlin, Renato Haddad, R. Graham Cooks, Marcos N. Eberlin and Rodinei Augusti, "Ambient Eberlin Reactions via Desorption Electrospray Ionization" , Journal of Mass Spectrometry , 2006 , 41(9), 1242-1264, doi: 10.1002/jms.1088

Brandy L. Young, R. G. Cooks, Scott A. Miller, Michelle C. Madden, Michael Bair, Jingpin Jia, "Chiral Purity Assay for Flindokalner using Tandem Mass Spectrometry: Method Development, Validation, and Benchmarking" , Journal of Pharmaceutical and Biomedical Analysis , 2007 , 43, 5, 1602-1608, 10.1016/j.jpba.2006.12.027

Zhengzheng Pan, Haiwei Gu, Nari Talaty, Huanwen Chen, Narasimhamurthy Shanaiah, Bryan E. Hainline, R. Graham Cooks, Daniel Raftery, "Principal component analysis of urine metabolites detected by NMR and DESI-MS in patients with inborn errors of metabolism" ,
Analytical and Bioanalytical Chemistry , 2007 , 387(2), 539doi: 10.1007/s00216-006-0546-7

Haiwei Gu, Huanwen Chen, Zhengzheng Pan, Ayanna U. Jackson, Nari Talaty, Bowei Xi, Candice Kissinger, Chester Duda, Doug Mann, Daniel Raftery and R. Graham Cooks, "Monitoring Diet Effects from Biofluids and Their Implications for Metabolomics Studies" , Analytical Chemistry , 2007 , 79(1), 89-97, doi: 10.1021/ac060946c

Demian R. Ifa, Justin M. Wiseman, Qingyu Song, R. Graham Cooks, "Development of Capabilities for Imaging Mass Spectrometry under Ambient Conditions with Desorption Electrospray Ionization (DESI)" , International Journal of Mass Spectrometry , 2007 , 259, 1-3, 8-15, doi: 10.1016/j.ijms.2006.08.003

Brandy L. Young and R. Graham Cooks, "Improvements in Quantitative Chiral Determinations using the Mass Spectrometric Kinetic Method" , International Journal of Mass Spectrometry , 2007 , 267, 1-3, 199-204, doi: 10.1016/j.ijms.2007.02.036

Sergio C. Nanita, Ewa Sokol and R. Graham Cooks, "Alkali Metal-Cationized Serine Clusters Studied by Sonic Spray Ionization Tandem Mass Spectrometry" , Journal of the American Society of Mass Spectrometry , 2007 , 18, 5, 856-868, doi: 10.1016/j.jasms.2007.01.003

Hao Chen, Livia S. Eberlin and R. Graham Cooks, "Neutral Fragment Mass Spectra after Ambient Thermal Dissociation of Peptide and Protein Ions" , Journal of the American Chemical Society , 2007 , 129, 5880-5886, doi: 10.1021/ja067712v

Yishu Song, Nari Talaty, Andy W. Tao, Zhengzheng Pan and R. Graham Cooks, "Rapid Ambient Mass Spectrometric Profiling of Intact, Untreated Bacteria using Desorption Electrospray Ionization" , Chemical Communications , 2007 , 61-63, doi: 10.1039/b615724f

Scott A. Smith, Thomas A. Blake, Demian R. Ifa, R. Graham Cooks, Zheng Ouyang, "Dual-Source Mass Spectrometer with MALDI-LIT-ESI Configuration" , Journal of Proteome Research , 2007 , 6 (2), 837-845, doi: 10.1021/pr060514i

Perry, R. H., Wu, C., Nefliu, M., and Cooks, R. G., "Serine Sublimes with Spontaneous Chiral Amplification" , Chemical Communications , 2007 , 1071-1073, doi: 10.1039/b616196k

Ouyang, Z.; Gao, L.; Fico, M.; Chappell, W. J.; Noll, R. J.; Cooks, R. G, "Quadrupole Ion Traps and Trap Arrays: Geometry, Material, Scale, Performance" , European Journal of Mass Spectrometry , 2007 , 13, 1, 13-18, doi: 10.1255/ejms.832

Qizhi Hu, R. Graham Cooks and Robert J. Noll, "Phase-Enhanced Selective Ion Ejection in an Orbitrap Mass Spectrometer" , Journal of the American Society of Mass Spectrometry , 2007 , 18, 6, 980-983, doi: 10.1016/j.jasms.2007.02.004

Dina R. Justes, Nari Talaty, I. Cotte-Rodriguez, R. Graham Cooks, "Detection of Explosives on Skin using Ambient Ionization Mass Spectrometry" , Chemical Communications , 2007 , 2142-2144, DOI: 10.1039/b703655h

Yishu Song and R. Graham Cooks, "Reactive Desorption Electrospray Ionization for Selective Detection of the Hydrolysis Products of Toxic Phosphonate Esters" , Journal of Mass Spectrometry , 2007 , 42, 8, 1086-1092, doi: 10.1002/jms.1244

J. M. Wiseman, D. R. Ifa and R. Graham Cooks, "Electrosonic Spray Ionization" , Encyclopedia of Mass Spectrometry, M. L. Gross (ed.) , 2007 , in press,

Nari Talaty, Zoltan Takats, Justin M. Wiseman and R. Graham Cooks, "Desorption Electrospray Ionization (DESI)" , Encyclopedia of Mass Spectrometry, M. L. Gross (ed.) , 2007 , in press,

Z. Ouyang, P. Yang and R. Graham Cooks, "Fast Desolvation with High Velocity Gas Flow" , Encyclopedia of Mass Spectrometry, M. L. Gross (ed.) , 2007 , in press,

Andre Venter and R. Graham Cooks, "Extractive electrospray ionization" , Encyclopedia of Mass Spectrometry, M. L. Gross (ed.) , 2007 , in press,

Ouyang, Z., Gao, L., Fico, M., Chappell, W. J., Noll, R. J., Cooks, R. G., "Quadrupole Ion Traps and Trap Arrays: Geometry, Material, Scale, Performance" , Advances In Mass Spectrometry , 2007 , in press,

Julia Laskin, Peng Wang, Omar Hadjar, Jean H. Futrell, Jormarie Alvarez, and R. Graham Cooks, "Charge Retention by Peptide Ions Soft-Landed onto Self-Assembled Monolayer Surfaces" , International Journal of Mass Spectrometry , 2007 , 265, 2-3, 237-243, doi:10.1016/j.ijms.2007.02.013

Liang Gao, Qingyu Song, Robert J. Noll, Jason Duncan, R. Graham Cooks and Zheng Ouyang, "Glow Discharge Electron Impact Ionization Source for Miniature Mass Spectrometers" , Journal of Mass Spectrometry , 2007 , 42, 5, 675-680, doi: 10.1002/jms.1201

Demian R Ifa, Luke Gumaelius, Livia S Eberlin, Nicholas E Manicke and R Graham Cooks, "Forensic Analysis of Inks by Imaging Desorption Electrospray Ionization (DESI) Mass Spectrometry" , Analyst , 2007 , 132, 461-467, doi:10.1039/b700236j

Tiina J. Kauppila, Nari Talaty, Tiia Kuuranne, Tapio Kotiaho, Risto Kostiainen and R. Graham Cooks, "Rapid Analysis of Metabolites and Drugs of Abuse from Urine Samples by Desorption Electrospray Ionization-Mass Spectrometry" , Analyst , 2007 , 132, 9, 868-875, 10.1039/b703524a

Ayanna U Jackson, Nari Talaty, R. G. Cooks and Gary J. Van Berkel, "Salt Tolerance of Desorption Electrospray Ionization (DESI)" , Journal of the American Society of Mass Spectrometry , 2007 , 18, 12, 2218-2225, doi: 10.1016/j.jasms.2007.09.018

Miriam Fico, Meng Yu, Zheng Ouyang, R. Graham Cooks, William J. Chappell, "Miniaturization and Geometry Optimization of a Polymer-Based Rectilinear Ion Trap" , Analytical Chemistry , 2007 , 79, 8076-8082, 10.1021/ac0711384

Andre Venter, R.Graham Cooks, "Desorption electrospray ionization in a small pressure tight enclosure" , Analytical Chemistry , 2007 , 79(16): , 6398-6403, doi:10.1021/ac0708846

Anthony B. Costa, R. Graham Cooks, "Simulation of Atmospheric Transport and Droplet Thin-Film Collisions in Desorption Electrospray Ionization" , Chemical Communications , 2007 , 3915-3917, doi: 10.1039/b710511h

Ismael Cotte-Rodríguez, Christopher C. Mulligan, and R. Graham Cooks, "Non-Proximate Detection of Small and Large Molecules by Desorption Electrospray Ionization and Desorption Atmospheric Pressure Chemical Ionization Mass Spectrometry: Instrumentation and Applications in Forensics, Chemistry, and Biology" , Analytical Chemistry , 2007 , 79 (18), 7069-7077, doi: 10.1021/ac0707939

Adam Keil, Nari Talaty, Christian Janfelt, Robert J. Noll, Liang Gao, Zheng Ouyang, R.Graham Cooks, "Ambient Mass Spectrometry with a Handheld Mass Spectrometer at High Pressure" , Analytical Chemistry , 2007 , 79, 7734-7739, doi:10.1021/ac071114x

Huang GM, Chen H, Zhang XR, Cooks RG, Ouyang Z, "Rapid screening of anabolic steroids in urine by reactive Desorption Electrospray Ionization " , Analytical Chemistry , 2007 , 79(21), 8327-8332, DOI: 10.1021/ac0711079

Cotte-Rodriguez, Ismael, Hernández-Soto, Heriberto, Chen, Hao, Cooks, R. Graham, "In Situ Trace Detection of Peroxide Explosives by Desorption Electrospray Ionization and Desorption Atmospheric Pressure Chemical Ionization " , Analytical Chemistry , 2008 , 80(5), 1512-1519, DOI: 10.1021/ac7020085

Marcela Nefliu, Jonell N. Smith, Andre Venter, and R. Graham Cooks, "Internal Energy Distributions in Desorption Electrospray Ionization (DESI)" , Journal of the American Society of Mass Spectrometry , 2008 , 19, 420-427,

Adam Keil, Heriberto Hernandez-Soto, Robert J. Noll, Miriam Fico, Liang Gao, Zheng Ouyang, R. Graham Cooks, "Monitoring of Toxic Compounds in Air Using an Handheld Rectilinear Ion Trap Mass Spectrometer" , Analytical Chemistry , 2008 , 80, 734-741, doi: 10.1021/ac070906o

Michael Volný, Andre Venter, Scott A. Smith, Marco Pazzi and R. Graham Cooks, "Surface effects and Electrochemical Cell Capacitance in Desorption Electrospray Ionization" , Analyst , 2008 , 132(4), 525-531, DOI: 10.1039/b717693g

Andre Venter, Marcela Nefliu, R. Graham Cooks, "Ambient Desorption Ionization Mass Spectrometry" , Trends in Analytical Chemistry , 2008 , 27, 284-290, doi:10.1016/j.trac.2008.01.010

Perry. R. H., Cooks, R. G. and Noll, R. J., "Orbitrap Mass Spectrometry: Instrumentation, Ion Motion and Applications" , Mass Spectrometry Reviews , 2008 ,

Demian R Ifa, Nicholas E Manicke, Allison L Rusine and R Graham Cooks, "Quantitative Analysis of Small Molecules by Desorption Electrospray Ionization (DESI) Mass Spectrometry from PTFE surfaces" , Rapid Communications in Mass Spectrometry , 2008 , 22, 503-510, doi: 10.1002/rcm.3377

Ayanna U. Jackson, Sean R. Werner, Nari Talaty, Yishu Song, Karinna Campbell, John A. Morgan, R. Graham Cooks, "Targeted Metbolomic Analysis of Escherichia coli by Desorption Electrospray Ionization and Extractive Electrospray Ionization Mass Spectrometry" , Analytical Biochemistry , 2008 , 375 (2), 272-281,

Justin M Wiseman, Demian R Ifa, Andre Venter, R Graham Cooks, "Ambient molecular imaging by desorption electrospray ionization mass spectrometry" , Nature Protocols , 2008 , 3(3), 517-524, doi: 10.1038/nprot.2008.11

H. Chen, L. S. Eberlin, M. Nefliu, R. Augusti, R. G. Cooks, "Organic Reactions of Ionic Intermediates Promoted by Atmospheric-Pressure Thermal Activation" , Angewandte Chemie International Edition , 2008 , 47, 3422-3425, DOI: 10.1002/anie.200800072

Nicholas E. Manicke, Justin M. Wiseman, Demian R. Ifa, R. Graham Cooks, "Desorption Electrospray Ionization (DESI) Mass Spectrometry and Tandem Mass Spectrometry (MS/MS) of Phospholipids and Sphingolipids: Ionization, Adduct Formation, and Fragmentation" , Journal of the American Society of Mass Spectrometry , 2008 , 19, 531-543,

Tiina J. Kauppila, Nari Talaty, Ayanna U. Jackson, Tapoi Kotiaho, Risto Kostiainen, R. Graham Cooks, "Carbohydrate and steroid analysis by desorption electrospray ionization mass spectrometry" , Chemical Communications , 2008 , 2674-2676, DOI: 10.1039/b804413a

Wen-Ping Peng, Mike Goodwin, Zongxiu Nie, Michael Volný, Zheng Ouyang and R. Graham Cooks, "Ion Soft Landing using Novel Rectilinear Ion Trap Mass Spectrometer " , Analytical Chemistry , 2008 , 80, 6640-6649, doi:10.1021/ac800929w

Demian R Ifa, Nicholas E Manicke, Allison L Dill and R Graham Cooks, "Latent Fingerprint Chemical Imaging by Mass Spectrometry" , Science , 2008 , 321, 805-805, doi: 10.1126/science.1157199 (Full Text)

Liang Gao, R. Graham Cooks, Zheng Ouyang, "Breaking the Pumping Speed Barrier in Mass Spectrometry: Discontinuous Atmospheric Pressure Interface" , Analytical Chemistry , 2008 , 80, 4026-4032, doi:10.1021/ac800014v

Justin M. Wiseman, Demian R. Ifa, Yongxin Zhu, Candice B. Kissinger, Nicholas E. Manicke, Peter T. Kissinger and R. Graham Cooks, "Desorption electrospray ionization mass spectrometry: Imaging drugs and metabolites in tissues" , Proceedings of the National Academy of Sciences , 2008 , accepted, doi:10.1073/pnas.0801066105

Na Na, Yu Xia, Zhenli Zhu, Xinrong Zhang and R. Graham Cooks, "Benzene Redox Reactions in Atmospheric Pressure Low Temperature Plasmas" , Journal of the American Chemical Society , 2008 , submitted,

Lívia S. Eberlin, Yu Xia, Hao Chen and R. Graham Cooks*, "Atmospheric Pressure Thermal Dissociation of Phospho- and Sulfopeptides" , Journal of the American Society of Mass Spectrometry , 2008 , in press,

Qingyu Song, Scott A. Smith, Liang Gao, Michael Volný, Ouyang Zheng, R. Graham Cooks, "Beam type Mass-selective Waveform Isolation in Quadrupoles" , Analytical Chemistry , 2008 , submitted,

Perry, R. H.; Hu, Q.; Salazar, G. A.; Noll, R. J.; Cooks, R. G. , "Rephasing the Ion Population in the Orbitrap Mass Analyzer for Improvement in Analytical Performance" , Analytical Chemistry , 2008 , in preparation,

Salazar, G. A.; Perry, R. H.; Cooks, R. G. , "A Novel Desorption Electrospray Ionization (DESI) Source for Analysis of Large Surface Areas" , Analytical Chemistry , 2008 , in preparation,
Yu Xia, Zheng Ouyang, R. Graham Cooks, "Peptide Fragmentation in NanoESI Assisted by Low Temperature Plasma Treated Surfaces" , Angewandte Chemie International Edition , 2008 , accepted,

Sanders, N. L.; Sokol, E., Perry, R. H.; Huang, G. M.; Noll, R. J.; Cooks, R. G., "Handheld Mass Spectrometer for Environmental Analysis Using a Variety of Sampling and Ionization Methods" , Journal of Mass Spectrometry , 2008 , In preparation,

Anthony B Costa, R. Graham Cooks, "Simulated Splashes: Elucidating the Mechanism of Desorption Electrospray Ionization Mass Spectrometry" , Chemical Physics Letters , 2008 , In Press, doi: 10.1016/j.cplett.2008.08.020

Nari Talaty, Christopher C. Mulligan, Dina R. Justes, Ayanna U. Jackson, Robert J. Noll and R. Graham Cooks, "Fabric analysis by ambient mass spectrometry for explosives and drugs" , Analyst , 2008 , doi: 10.1039/b807934j

Ewa Sokol, Kathleen E. Edwards, Kuangnan Qian and R. Graham Cooks, "Rapid hydrocarbon analysis using a miniature rectilinear ion trap mass spectrometer" , Analyst , 2008 , 133, 1064-1071, doi 10.1039/b805813j

Jason D. Harper, Nicholas A.Charipar, Christopher C. Mulligan, R. Graham Cooks, and Zheng Ouyang, "Low Temperature Plasma Probe for Ambient Desorption Ionization" , Analytical Chemistry , 2008 , submitted,

Liang Gao, Andy Sugiarto, Jason D. Harper, R. Graham Cooks, Zheng Ouyang, "Design and Characterization of a Multisource Hand-Held Tandem Mass Spectrometer" , Analytical Chemistry , 2008 , Accelerated Article, doi: 10.1021/ac801275x