Chercheurs

Sciences de la Vie / ACKERMANN, MARTIN

martin.ackermann

Position

Associate Professor of Molecular Microbial Ecology at ETH Zurich since August, 2008.

Leader of the Molecular Microbial Ecology group of the ETH Zurich, which is part of the Institute of Biogeochemistry and Pollutant Dynamics at the Department of Environmental Systems Science, and the Eawag Department of Environmental Microbiology.

Thèmes de recherche

Martin Ackermann's group uses experimental evolution with bacteria to investigate fundamental questions about evolutionary biology. The main focus is on phenotypic variation - phenotypic differences between individuals with or without underlying genetic differences. The group investigates how selection acts on the mechanisms that control the level of phenotypic variation, and how the level of phenotypic variation can influence the course of evolution. A second area of research is the evolutionary origin of aging. Experiments with bacteria are used together with theoretical models to investigate when and why aging originated in the history of life.

Prix et récompenses

Publications

2012
Arnoldini, M, Mostowy, R, Bonhoeffer, S, Ackermann, M
Evolution of Stress Response in the Face of Unreliable Environmental Signals
PLOS COMPUTATIONAL BIOLOGY (2012) 8:-

Bergmiller, T, Ackermann, M, Silander, OK
Patterns of Evolutionary Conservation of Essential Genes Correlate with Their Compensability
PLOS GENETICS (2012) 8:-

Helbling, DE, Ackermann, M, Fenner, K, Kohler, HPE, Johnson, DR
The activity level of a microbial community function can be predicted from its metatranscriptome
ISME JOURNAL (2012) 6:902-904

Pena-Miller, R, Lahnemann, D, Schulenburg, H, Ackermann, M, Beardmore, R
Selecting Against Antibiotic-Resistant Pathogens: Optimal Treatments in the Presence of Commensal Bacteria
BULLETIN OF MATHEMATICAL BIOLOGY (2012) 74:908-934

Stecher, B, Denzler, R, Maier, L, Bernet, F, Sanders, MJ, Pickard, DJ, Barthel, M, Westendorf, AM, Krogfelt, KA, Walker, AW, Ackermann, M, Dobrindt, U, Thomson, NR, Hardt, WD
Gut inflammation can boost horizontal gene transfer between pathogenic and commensal Enterobacteriaceae
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012) 109:1269-1274

Silander, Olin K, Nikolic, Nela, Zaslaver, Alon, Bren, Anat, Kikoin, Ilya, Alon, Uri, Ackermann, Martin
A Genome-Wide Analysis of Promoter-Mediated Phenotypic Noise in Escherichia coli.
PLoS Genetics (2012) 8:e1002443-

2011
Bergmiller, Tobias, Ackermann, Martin
Pole Age Affects Cell Size and the Timing of Cell Division in Methylobacterium extorquens AM1
JOURNAL OF BACTERIOLOGY (2011) 193:5216-5221

Sturm, Alexander, Heinemann, Matthias, Arnoldini, Markus, Benecke, Arndt, Ackermann, Martin, Benz, Matthias, Dormann, Jasmine, Hardt, Wolf-Dietrich
The Cost of Virulence: Retarded Growth of Salmonella Typhimurium Cells Expressing Type III Secretion System 1
PLOS PATHOGENS (2011) 7:-

Bergmiller, Tobias, Pena-Miller, Rafael, Boehm, Alexander, Ackermann, Martin
Single-cell time-lapse analysis of depletion of the universally conserved essential protein YgjD
BMC MICROBIOLOGY (2011) 11:-

Pecson, Brian M., Ackermann, Martin, Kohn, Tamar
Framework for Using Quantitative PCR as a Nonculture Based Method To Estimate Virus Infectivity
ENVIRONMENTAL SCIENCE & TECHNOLOGY (2011) 45:2257-2263

2010
Boehm, A, Kaiser, M, Li, H, Spangler, C, Kasper, CA, Ackermann, M, Kaever, V, Sourjik, V, Roth, V, Jenal, U
Second Messenger-Mediated Adjustment of Bacterial Swimming Velocity
CELL (2010) 141:107-116

2009
Novak, M, Pfeiffer, T, Ackermann, M, Bonhoeffer, S
Bacterial growth properties at low optical densities
ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY (2009) 96:267-274

Boehm, A, Steiner, S, Zaehringer, F, Casanova, A, Hamburger, F, Ritz, D, Keck, W, Ackermann, M, Schirmer, T, Jenal, U
Second messenger signalling governs Escherichia coli biofilm induction upon ribosomal stress
MOLECULAR MICROBIOLOGY (2009) 72:1500-1516

Silander, OK, Ackermann, M
The constancy of gene conservation across divergent bacterial orders
BMC Research Notes (2009) 2:-

2008
Freed, NE, Silander, OK, Stecher, B, Bohm, A, Hardt, WD, Ackermann, M
A Simple Screen to Identify Promoters Conferring High Levels of Phenotypic Noise
PLOS GENETICS (2008) 4:-

Wanner, RM, Guthlein, C, Bottger, EC, Springer, B, Ackermann, M
Stabilization of the genome of the mismatch repair deficient Mycobacterium tuberculosis by context dependent codon choice
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY (2008) 298:66-66

Ackermann, M, Stecher, B, Freed, NE, Songhet, P, Hardt, WD, Doebeli, M
Self-destructive cooperation mediated by phenotypic noise
NATURE (2008) 454:987-990

Wanner, RM, Guthlein, C, Springer, B, Bottger, EC, Ackermann, M
Stabilization of the genome of the mismatch repair deficient Mycobacterium tuberculosis by context-dependent codon choice
BMC GENOMICS (2008) 9:-

Ackermann, M
Bacteria as a new model system for aging studies: Investigations using light microscopy
BIOTECHNIQUES (2008) 44:564-567

2007
Ackermann, M, Pletcher, SD
Chapter 18: Evolutionary biology as a foundation for studying aging and aging-related disease
Evolution in Health and Disease (2007) 1:-

Ackermann, M, Schauerte, A, Stearns, SC, Jenal, U
Experimental evolution of aging in a bacterium
BMC EVOLUTIONARY BIOLOGY (2007) 7:-

Ackermann, M, Chao, L, Bergstrom, CT, Doebeli, M
On the evolutionary origin of aging
AGING CELL (2007) 6:235-244

2006
Ackermann, M, Chao, L
DNA sequences shaped by selection for stability
PLOS GENETICS (2006) 2:224-230

Salathe, M, Ackermann, M, Bonhoeffer, S
The effect of multifunctionality on the rate of evolution in yeast
MOLECULAR BIOLOGY AND EVOLUTION (2006) 23:721-722

2004
Ackermann, M, Doebeli, M
Evolution of niche width and adaptive diversification
EVOLUTION (2004) 58:2599-2612

Ackermann, M, Chao, L
Evolution of cooperation: Two for one?
CURRENT BIOLOGY (2004) 14:R73-R74

2003
Ackermann, M, Stearns, SC, Jenal, U
Senescence in a bacterium with asymmetric division
SCIENCE (2003) 300:1920-1920

2002
Denecker, G, Totemeyer, S, Mota, LJ, Troisfontaines, P, Lambermont, I, Youta, C, Stainier, I, Ackermann, M, Cornelis, GR
Effect of low- and high-virulence Yersinia enterocolitica strains on the inflammatory response of human umbilical vein endothelial cells
INFECTION AND IMMUNITY (2002) 70:3510-3520

2001
Kern, S, Ackermann, M, Stearns, SC, Kawecki, TJ
Decline in offspring viability as a manifestation of aging in Drosophila melanogaster
EVOLUTION (2001) 55:1822-1831

Ackermann, M, Bijlsma, R, James, AC, Partridge, L, Zwaan, BJ, Stearns, SC
Effects of assay conditions in life history experiments with Drosophila melanogaster
JOURNAL OF EVOLUTIONARY BIOLOGY (2001) 14:199-209

2000
Stearns, SC, Ackermann, M, Doebeli, M, Kaiser, M
Experimental evolution of aging, growth, and reproduction in fruitflies
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000) 97:3309-3313

1998
Stearns, SC, Ackermann, M, Doebeli, M
The experimental evolution of aging in fruitflies
EXPERIMENTAL GERONTOLOGY (1998) 33:785-792

1997
Doebeli, M, Blarer, A, Ackermann, M
Population dynamics, demographic stochasticity, and the evolution of cooperation
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1997) 94:5167-5171