KARPATI, GEORGE / Medicina / Investigadores

Centro Internacional de Investigación Científica





Canadian neurologist and neuroscientist (May 17, 1934 – February 6, 2009)

Former Izaak Walton Killam Chair and Professor of Neurology at McGill University and is a distinguished Clinician Scientist, Canada.

Dr. Karpati is recognized internationally as one of the leading experts on the diagnosis and treatment of neuromuscular disorders. He has made seminal contributions in the area of muscular dystrophy. He was the first to show the localization of dystrophin to the muscle fibre surface and to demonstrate a lack of dystrophin in the fibres of Duchenne patients. Dr. Karpati demonstrated pre-clinical success with adenovirus-mediated dystrophin gene replacement in mice.

His research covers a broad range of basic and clinical studies on neuromuscular and neurological disorders, utilizing a broad spectrum of technologies including clinical science, histology, cytochemistry, molecular biology and genetics. During 2001-2006, Dr. Karpati directed a large, CIHR-supported international consortium dedicated to molecular therapies of nervous system diseases.

Many honours and awards including the Order of Canada, the Royal Society of Canada, and a Lifetime Achievement Award in Neuromuscular Research and Clinics from the Muscular Dystrophy Association of Canada. In June 2005, he was appointed a Knight of the Ordre National du Québec and in November 2006 he was awarded the Prix du Québec (Wilder Penfield).

Matecki S, Dudley RW, Divangahi M, Gilbert R, Nalbantoglu J, Karpati G, Petrof BJ.
Therapeutic gene transfer to dystrophic diaphragm by an adenoviral vector deleted of all viral genes.
Am J Physiol Lung Cell Mol Physiol. 2004 May 21 [Epub ahead of print]
PMID: 15155269 [PubMed - as supplied by publisher]

Karpati G, Sinnreich M.
A clever road from myopathology to genes: the myotilin story.
Neurology. 2004 Apr 27;62(8):1248-9. No abstract available.
PMID: 15111657 [PubMed - in process]

Dudley RW, Lu Y, Gilbert R, Matecki S, Nalbantoglu J, Petrof BJ, Karpati G.
Sustained improvement of muscle function one year after full-length dystrophin gene transfer into mdx mice by a gutted helper-dependent adenoviral vector.
Hum Gene Ther. 2004 Feb;15(2):145-56.
PMID: 14975187 [PubMed - in process]

Karpati G, Sinnreich M.
The molecular era of myology.
J Neuropathol Exp Neurol. 2003 Dec;62(12):1203-10. Review.
PMID: 14692696 [PubMed - indexed for MEDLINE]

Karpati G, Nalbantoglu J.
The principles of molecular therapies for glioblastoma.
Int Rev Neurobiol. 2003;55:151-63. Review. No abstract available.
PMID: 12968535 [PubMed - indexed for MEDLINE]

Fan X, Messaed C, Dion P, Laganiere J, Brais B, Karpati G, Rouleau GA.
HnRNP A1 and A/B interaction with PABPN1 in oculopharyngeal muscular dystrophy.
Can J Neurol Sci. 2003 Aug;30(3):244-51.
PMID: 12945950 [PubMed - indexed for MEDLINE]

Karpati G.
Molecular therapies for the nervous system and muscle.
Ernst Schering Res Found Workshop. 2003;(43):159-78. Review. No abstract available.
PMID: 12894456 [PubMed - indexed for MEDLINE]

Dupre N, Howard HC, Mathieu J, Karpati G, Vanasse M, Bouchard JP, Carpenter S, Rouleau GA.
Hereditary motor and sensory neuropathy with agenesis of the corpus callosum.
Ann Neurol. 2003 Jul;54(1):9-18. Review.
PMID: 12838516 [PubMed - indexed for MEDLINE]

Gilbert R, Dudley RW, Liu AB, Petrof BJ, Nalbantoglu J, Karpati G.
Prolonged dystrophin expression and functional correction of mdx mouse muscle following gene transfer with a helper-dependent (gutted) adenovirus-encoding murine dystrophin.
Hum Mol Genet. 2003 Jun 1;12(11):1287-99.
PMID: 12761044 [PubMed - indexed for MEDLINE]

Dunant P, Walter MC, Karpati G, Lochmuller H.
Gentamicin fails to increase dystrophin expression in dystrophin-deficient muscle.
Muscle Nerve. 2003 May;27(5):624-7.
PMID: 12707984 [PubMed - indexed for MEDLINE]

Cerletti M, Negri T, Cozzi F, Colpo R, Andreetta F, Croci D, Davies KE, Cornelio F, Pozza O, Karpati G, Gilbert R, Mora M.
Dystrophic phenotype of canine X-linked muscular dystrophy is mitigated by adenovirus-mediated utrophin gene transfer.
Gene Ther. 2003 May;10(9):750-7.
PMID: 12704413 [PubMed - indexed for MEDLINE]

Karpati G, Holland P.
Sweetening the pot in muscle: genetic defects of protein glycosylation causing muscle disease.
Neurology. 2002 Dec 10;59(11):1674-6. Review. No abstract available.
PMID: 12473751 [PubMed - indexed for MEDLINE]

Danialou G, Comtois AS, Dudley RW, Nalbantoglu J, Gilbert R, Karpati G, Jones DH, Petrof BJ.
Ultrasound increases plasmid-mediated gene transfer to dystrophic muscles without collateral damage.
Mol Ther. 2002 Nov;6(5):687-93.
PMID: 12436962 [PubMed - indexed for MEDLINE]

Gilbert R, Liu A, Petrof B, Nalbantoglu J, Karpati G.
Improved performance of a fully gutted adenovirus vector containing two full-length dystrophin cDNAs regulated by a strong promoter.
Mol Ther. 2002 Oct;6(4):501-9.
PMID: 12377192 [PubMed - indexed for MEDLINE]

Sasarman F, Karpati G, Shoubridge EA.
Nuclear genetic control of mitochondrial translation in skeletal muscle revealed in patients with mitochondrial myopathy.
Hum Mol Genet. 2002 Jul 1;11(14):1669-81.
PMID: 12075011 [PubMed - indexed for MEDLINE]

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