MCCULLOCH, ERNEST A. / Medicina / Investigadores

Centro Internacional de Investigación Científica

Investigadores

Medicina / MCCULLOCH, ERNEST A.

mccullocuhnres.utoronto.ca

Puesto

Haematologist and scientist (27 April 1926 – 20 January 2011)

Former Senior Scientist
Division of Stem Cell and Developmental Biology,
Ontario Cancer Institute (OCI),
Toronto, Canada.

McCulloch and James Till were the first to prove the existence of stem cells more than 40 years ago while working at the Ontario Cancer Institute in Toronto.

Stem cells are able to develop into other kinds of cells or tissue. Scientists are examining adult and embryonic stem cells in hopes of treating different diseases.

They showed that a single kind of bone marrow stem cell could create the three main kinds of blood cells. Their work also explained the effects of treatments for leukemia and other blood cancers.

2005 Albert Lasker Award for Basic Medical Research, with James Till

McCulloch, E. and Till, J.E. (1960) The radiation sensitivity of normal mouse bone marrow cells, determined by quantitative marrow transplantation into irradiated mice. Rad. Res. 13: 115-125.

Till, J.E. and McCulloch, E.A. (1961) A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Rad. Res. 14: 213-222.

Becker, A.J., McCulloch, E.A. and Till, J.E. (1963) Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells. Nature 197: 452.

Siminovitch, L., McCulloch, E.A., and Till, J.E. (1963) The distribution of clony-forming cells among spleen colonies. J. Cell. Comp. Physio. 62: 327.

Till, J.E., McCulloch, E.A., and Siminovitch, L. (1964) A stochastic model of stem cell proliferation, based on the growth of spleen colony-forming cells. Proc. Natl. Acad. Sci. USA 51: 29-36.

McCulloch, E.A. Siminovitch, L., and Till, J.E. (1964) Spleen colony formation in anemic mice of genotype W/Wv. Science 144: 844-846.

McCulloch, E.A., Siminovitch, L., Till, J.E., Russell, E.S., and Bernstein, S.E. (1965) The cellular basis of the genetically determined hemopoietic defect in anemic mice of genotype Sl/Sld. Blood 26: 399-410.

Till, J.E. and McCulloch E.A. (1980) Hemopoietic stem cell differentiation. Biochimica et Biophysica Acta 605: 431-459.

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