MONTAGNIER, LUC / Medicina / Investigadores

Centro Internacional de Investigación Científica




Professor emeritus and Director, World Foundation for AIDS Research and Prevention, Paris, France.

In 1983, as head of the Viral Oncology Unit at the Pasteur Institute in Paris, he and his colleagues discovered the human retrovirus later to be known as HIV-1, the etiologic agent of AIDS.

In 1985, his team isolated the second human AIDS virus, HIV-2, from West African patients. Since 1986, he has coordinated the work of a distinguished group of collaborators on the mechanisms of AIDS pathogenesis.

The main directions of his research are now the mechanisms by which HIV induces the decline of CD4 lymphocytes, the regulation of virus latency and expression, and HIV-induced encephalopathy. In 1991, his laboratory first described the high propensity of cultured lymphocytes from HIV-infected individuals to die by apoptosis, even though most cells were not infected. This phenomenon could account at least in part for the depletion of CD4 lymphocytes, which is the hallmark of the disease, and could be caused by the interaction of the virus coat protein with its receptor on the cell surface. Other mechanisms are also being investigated, such as chronic activation associated with oxidative stress. In particular he has been involved in the search for infectious cofactors of AIDS. Foremost among the possible cofactors is a newly discovered species of Mycoplasma, M. penetrans.

Rosen Prize(1971)
Gallien Prize (1985)
Jeantet Prize (19BG)
Lasker Prize (1986)
Gairdner Prize (1987)
Santé (1987)
Japan Prize (1988)
King Faisal Prize (1993)
Dr A.H. Heineken Prize for Medicine (1994)
Nobel Prize in Physiology or Medicine (2008)

Chevalier de la Légion d\'Honneur (1984)
Commandeur de l\'Ordre National du Mérite (1986)
Officier de la Légion d\'Honneur (1990) Commandeur de la Légion d\'Honneur (1993)

Montagnier L, Brenner C, Chamaret S, Guetard D, Blanchard A, de Saint Martin J, Poveda JD, Pialoux G, Gougeon ML 1997. Human immunodeficiency virus infection and AIDS in a person with negative serology. J. Infect. Dis. 175: 955-959.

M.L. Gougeon, H. Lecoeur, A. Dulioust, M.G. Enouf, M. Crouvoiser, C. Goujard, T. Debord,and L. Montagnier 1996. Programmed cell death in peripheral lymphocytes from HIV-infected persons - increased susceptibility to apoptosis of CD4 and CD8 T-cells correlates with lymphocyte activation and with disease progression. J. Immunol. 156: 3509-3520.

L. Montagnier 1996. Environmental pathogenesis of human retrovir-uses. AIDS Res. Hum. Retroviruses 12: 357-359.

L. Montagnier and A. Blanchard 1993. Mycoplasmas as cofactors in infection due to the human immunodeficiency virus. Clin. Inf. D. 17: S309-S315.

L. Montagnier, D. Berneman, D. Guetard, A. Blanchard, S. Chamaret, V. Rame, S. Vanrietschoten, K. Mabrouk, and E. Bahraoui 1990. Inhibition of HIV prototype strain infectivity by antibodies directed against a peptidic sequence of mycoplasma. Compt Rend Acad Sci III 311: 425-430.

M. Ernerman, M. Guyader, L. Montagnier, D. Baltimore, and M.A. Muesing 1987. The specificity of the human immunodeficiency virus type 2 transactivator is different from that of human immunodeficiency virus type 1. EMBO J 6:3755-60.

L. Montagnier, J. Gruest, S. Chamaret, C. Dauguet, C. Axler, D. Guetard, M.T. Nugeyre, F. Barresin, J.C. Chermann, J.B. Brunet 1984. Adaptation of lympadenopathy-associated virus (LAV) to application in EBV- transformed Blymphoblastoid cell lines. Science 225: 63-66.

D. Klatzmann, F. Barre-Sinousi, M.T. Nugeyre, C. Dauguet, E. Vilmer, C. Griscelli, F. Brun-Vezinet, C. Rouzioux, J.C. Gluckman, J.C. Cherman, and L. Montagnier 1984. Selective tropism of lympadenopathy- associated virus (LAV) for helper-inducer T cells. Science 225: 59-63.

D. Klatzmann, E. Champagne, S. Chamaret, J. Gruest, D. Guetard, T. Hercend, J.C. Gluckman, and L. Montagnier 1984. T-lymphocyte T4 molecule behaves as the receptor for human retrovirus IAV. Nature 312: 767-768.

L. Montagnier, C. Dauguet, C. Axler, S. Chamaret, J. Gruest, M.T. Nugeyre, F. Rey, F. Barresin, and J.C. Chermann 1984. A new type of retrovirus isolated from patients presenting with lymphadenopathy and acquired immune deficiency syndrome: structural and antigenic relatedness with equine infectious anemia virus. Ann. Virol. 135: 119.

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