CHANGEUX, JEAN-PIERRE / Ciencias de la Vida / Investigadores

Centro Internacional de Investigación Científica

Investigadores

Ciencias de la Vida / CHANGEUX, JEAN-PIERRE

Changeuxpasteur.fr

Puesto

Neurobiologiste
Professeur au Collège de France (Chaire de communication cellulaire) et à l'Institut Pasteur, Laboratoire de Neurobiologie Moléculaire.
Membre de l'Académie des Sciences.

- protéines allostériques (1959-1966),
- récepteur de l'acétycholine (depuis 1966),
- développement du système nerveux (depuis 1973)

- 1998 : médaille Linus-Pauling.
- 1997 : Grand prix de la Fondation pour la recherche médicale.
- 1996 : Max-Delbrück Medal.
- 1995 : prix international Camera-Exposition "L'Ame au corps" (avec Jean Clair).
- 1994 : Goodman and Gilman Award, Golgi Medal de l'Academia nazionale dei lincei, et Sir Hans Krebs Medal FEBS (Helsinki).
- 1993 : prix Jeantet de médecine, Genève.
- 1992 : médaille d'or du CNRS.
- 1991 : médaille Carl-Gustav-Bernhard de l'Académie suédoise des sciences.
- 1990 : prix Bristol-Myers-Squibb du Neurosciences Research Institute.
- 1988 : prix Rita-Levi-Montalcini de la Fondation Fidia.
- 1986 : prix F.-O- Schmitt du Neursosciences Research Institute.
- 1985 : prix Céline.
- 1983 : prix littéraire Broquette-Gonin de l'Académie française pour L'Homme neuronal.
- 1982 : prix Richard-Lounsbery de l'Académie des sciences, prix scientifique de la fondation israélienne Ricardo-Wolf.
- 1980 : Harvey Lecture.
- 1978 : prix de la Fondation Gairdner.
- 1977 : prix Alexandre-Joannidès de l'Académie des sciences.

Membre de l'Institut, de l'Académie léopoldine des sciences (RFA), de l'Académie des sciences de Washington, de l'Académie royale des sciences de Suède, de l'Académie royale de médecine de Belgique et de l'Académie de médecine de Turin. Fondateur et membre de l'Academia Europaea, membre de l'Académie européenne des arts, sciences, et lettres, de l'Académie américaine des arts et des sciences, de l'Académie des sciences de Roumanie, docteur honoris causa de plusieurs universités.

- The feedback control mechanism of biosynthetic L-threonine deaminase
by L-isoleucine. Changeux, J.-P., Cold Spring Harb. Symp. Quant. Biol. 26,
pp. 313-318 (1961).

- Allosteric proteins and cellular control systems. Monod, J., Changeux,
J.-P., and Jacob, F., J. Mol. Biol. 6, 306-329 (1963).

- On the nature of allosteric transitions : a plausible model.
Monod, J., Wyman, J. and Changeux, J.-P., J. Mol. Biol. 12, 88-118 (1965).

- The use of a snake venom toxin to characterize the cholinergic receptor
protein. Changeux, J.-P., Kasai, M. and Lee C. Y., Proc. Natl. Acad. Sci. U.S.A.
67,1241-1247 (1970).

- Excitation in vitro of purified membrane fragments by cholinergic
agonists. Kasai, M., and Changeux, J.-P., J. Memb. Biol. 6, 81-88 (1971).

- A theory of the epigenesis of neuronal networks by selective stabilization
of synapses. Changeux, J.-P., Courrège, P. and Danchin. A., Proc. Natl. Acad. Sci.
U.S.A. 70, 2974-2978 (1973).

- Purification and properties of the cholinergic receptor protein from
Electrophorus electricus electroplax. Meunier, J.-C., Sealock, R., Oslen,
R. and Changeux, J.-P., Eur. J. Biochemistry 45, 371-394 (1974).

- Effects of local anesthetics and calcium on the interaction of
cholinergic ligands with the nicotinic receptor protein from Torpedo marmorata.
Cohen, J.-B., Weber, M. and Changeux, J.-P., Mol. Pharmacol.
10, 904-932 (1974).

- Regulation of the binding properties of the nicotinic receptor
protein by cholinergic ligands in membrane fragments from Torpedo marmorata.
Weber, M., David-Pfeuty, M.T. and Changeux, J.-P., Proc. Natl. Acad. Sci. U.S.A.
72, 3443-3447 (1975).

- The selective stabilization of developing synapses : a plausible
mechanism for the specification of neuronal networks. Changeux, J.-P.
and Danchin, A., Nature 264, 702-705 (1976).

- Fast kinetics studies on the interaction of a fluorescent agonist
with the membrane-bound acetylcholine receptor from T. marmorata.
Heidmann, T. and Changeux, J.-P., Eur. J. Biochem. 94, 255-279 (1979).

- Reconstitution of a functional acetylcholine receptor : incorporation
into artificial lipid vesicles and pharmacology of the agonist-controlled
permeability changes. Popot, J.-L., Cartaud, J. and Changeux, J.-P., Eur.
J. Biochem. 118, 203-214 (1981).

- Complete mRNA coding sequence of the acetylcholine binding subunit from
Torpedo marmorata acetylcholine receptor. A model for the transmembrane organization
of the polypeptide chain. Devillers-Thiery, A., Giraudat, J., Bentaboulet, M. and
Changeux, J.-P., Proc. Natl. Acad. Sci. U.S.A. 80, 2067- 2071 (1983).

- Time-resolved photolabeling by the noncompetitive blocker chlorpromazine
of the acetylcholine receptor in its transiently open and closed ion channel
conformations. Heidmann, T. and Changeux, J.-P., Proc. Natl. Acad. Sci. U.S.A.
81, 1897-1901 (1984)

- Image analysis of the heavy form of the acetylcholine receptor
from Torpedo marmorata. Bon, F., Lebrun, E., Gomel, J., Van Rapenbusch, R.,
Cartaud, J., Popot, J.-L. and Changeux, J.-P., J. Mol. Biol. 176, 205-237 (1984).

- Activity regulates the level of acetylcholine receptor alpha-subunit mRNA
in cultured chick myotubes. Klarsfeld, A. Changeux, J.-P., Proc. Natl. Acad. Sci.
U.S.A. 82, 4558--4562 (1985).

- Structure of the high affinity binding site for noncompetitive blockers
of the acetylcholine receptor : Serine-262 of the subunit is labeled by [3H]
chlorpromazine. Giraudat, J., Dennis, M., Heidmann, T., Chang, J.Y. and Changeux,
J.-P., Proc. Natl. Acad. Sci. U.S.A. 83, 2719-2723 (1986).

- A 5' flanking region of the chicken acetylcholine receptor a -subunit gene
confers tissue-specificity and developmental control of expression in transfected
cells. Klarsfeld, A., Daubas, P., Bourrachot, B. and Changeux, J.-P., Mol.
Cell. Biol. 7, 951-955 (1987).

- Amino-acids of the Torpedo marmorata acetylcholine receptor a -subunit
labeled by a photoaffinity ligand for the acetylcholine binding site. Dennis,
M., Giraudat, J., Kotzyba-Hibert, F., Goeldner, M., Hirth, C., Chang, J.Y., Lazure,
C., Chrétien, M. and Changeux, J.-P., Biochemistry 27, 2346-2357 (1988).

- Detection of the nicotinic acetylcholine receptor a -subunit mRNA by in
situ hybridization at neuromuscular junctions of 15-day old chick striated muscles.
Fontaine, B., Sassoon, D., Buckingham, M. and Changeux, J.-P., EMBO J. 7, 603-609 (1989).

- A simple model of prefrontal cortex function in delayed-response tasks.
Dehaene, S. and Changeux, J.-P., J. Cognitive Neurosci. 1, 244-261 (1989).

-Regulation of muscle AChR a -subunit gene expression by electrical activity ;
involvement of protein kinase C and Ca++. Klarsfeld, A., Laufer, R., Fontaine, B.,
Devillers-Thiery, A., Dubreuil, C. and Changeux, J.-P., Neuron 2, 1229-1236 (1989).

- Two adjacent MyoD1 binding sites regulate the expression of the
acetylcholine receptor a -subunit gene. Piette, J., Bessereau, J.-L.,
Huchet M. and Changeux, J.-P. Nature 345, 353-355 (1990).

- Mutations in the channel domain alter desensitization of
a neuronal nicotinic receptor. Revah, F., Bertrand, D., Galzi, J.L., Devillers-Thiérv,
A., Mulle, C., Hussy, N., Bertrand, S., Ballivet, M. and Changeux, J.-P.,
Nature 353, 846-849 (1991).

- Mutations in the channel domain if a neuronal nicotinic receptor
convert ion selectivity from cationic to anionic. Galzi, J.L., Devillers-Thiéry,
A., Hussy, N., Bertrand, S., Changeux, J.-P., and Bertrand, D.,
Nature 359, 500-504 (1992).

- Chimaeric nicotinic-serotonergic receptor combines distinct ligand bonding
and channel specificities. Eiselé, J.L., Bertrand, S., Galzi, J.-L.,
Devillers-Thierry, A., Changeux, J.-P. and Bertrand, D., Nature 366, 479-483 (1993).

- In vivo and in vitro analysis of electrical activity-dependent
expression of muscle acetylcholine receptor genes using adenovirus. Bessereau,
J.-L., Stratford-Perricaudet, L., Piette, J., Le Poupon, C. and Changeux, J.-P.,
Proc. Natl. Acad. Sci. USA 91, 1304-1308 (1994).

- Identification of a DNA element determining synaptic expression
of the mouse acetylcholine receptor d -subunit gene. Koike, S., Schaeffer,
L. and Changeux, J.-P. Proc. Natl. Acad. Sci 92, 10624-10628 (1995).

- Abnormal avoidance learning in mice lacking functional high-affinity
nicotine receptor in the brain. Picciotto, M., Zoli, M., Léna, C., Bessis, A.,
Lallemand, Y., Le Novère, N., Vincent, P., Merlo Pich, E., Brûlet, P. and Changeux,
J.-P. Nature 374, 65-67 (1995).

- Identification of calcium binding sites that regulate potentiation
of a neuronal nicotinic acetylcholine receptor. Galzi, J.-L., Bertrand, S.,
Corringer, P.J., Changeux, J.-P. and Bertrand, D. EMBO J. 15, 5824-5832 (1996).

- Acetylcholine receptors containing b 2-subunit are involved in the
reinforcing properties of nicotine. Picciotto, M., Zoli, M., Rimondini, R.,
Léna, C., Marubio, L., Merlo Pich, E., Fuxe, K. et Changeux, J.-P.
Nature 391, 173-177 (1998).

- Implication on an Ets and Notch related transcription factor
in synaptic expression of the nicotinic acetylcholine receptor. Schaeffer,
L., Duclert, N., Huchet, M. et Changeux, J.-P. EMBO J. 17, 3078-3090 (1998).


Ouvrages :

- L'Homme neuronal (1983), Fayard, Paris.

- Matière à pensée (1984) (avec A. Connes), O. Jacob, Paris.

- Les Fondements naturels de l'éthique (collectif) (1993), dir. Changeux J.-P.,
O. Jacob, Paris.

- Raison et Plaisir (1994), O. Jacob, Paris.

- La Nature et la Règle (1998) (avec Paul Ricoeur), O. Jacob, Paris.

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