JEFFREYS, ALEC JOHN / Medicine / Researchers

International Center for Scientific Research

Researchers

Medicine / JEFFREYS, ALEC JOHN

ajjle.ac.uk

Position

Professor (Human genetics),
Department of Genetics
University of Leicester
Leicester, U.K.

Research interests

Analysis of human genome instability and recombination processes by single gamete and transgenic approaches. Investigation of the effects of ionising radiation on germline mutation.

Professor Jeffreys discovered one of the most important tools for identifying human beings, genetic fingerprinting.

Jeffreys and his team are now studying the effects of chronic irradiation such as that which has followed the melt down of the nuclear reactor at Chernobyl. Other areas of interest include analysis of human genome instability and recombination processes by single gamete and transgenic approaches. He is also investigating the effects of ionising radiation on germline mutation.

Prizes and awards

1996 : Albert Einstein World Award of Science

1998 : Australia Prize

2004 Louis Jantet Prize for Medicine

2005 Lasker Award for clinical medical research, with Edwin Southern of Oxford University, "for development of two powerful technologies - Southern hybridization and DNA fingerprinting - that together revolutionized human genetics and forensic diagnostics".

Publications

Yauk CL, Bois PR, Jeffreys AJ. (2003) High-resolution sperm typing of meiotic recombination in the mouse MHC E(beta) gene. EMBO J. 22:1389-1397.

Kauppi L, Sajantila A, Jeffreys AJ. (2003) Recombination hotspots rather than population history dominate linkage disequilibrium in the MHC class II region. Hum Mol Genet. 12:33-40.

Stead JD, Jeffreys AJ. (2002) Structural analysis of insulin minisatellite alleles reveals unusually large differences in diversity between Africans and non-Africans. Am J Hum Genet. 71:1273-84.

May CA, Shone AC, Kalaydjieva L, Sajantila A, Jeffreys AJ. (2002) Crossover clustering and rapid decay of linkage disequilibrium in the Xp/Yp pseudoautosomal gene SHOX. Nat Genet. 31:272-5.

Jeffreys AJ, Neumann R. (2002) Reciprocal crossover asymmetry and meiotic drive in a human recombination hot spot. Nat Genet. 31:267-71.

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