Founding Member of the Whitehead Institute for Biomedical Research and Professor of Biology at the Massachusetts Institute of Technology.
Dr. Jaenisch is a pioneer in transgenic science (making mouse models of human disease). These methods have been used to explore basic questions such as the role of DNA modification, genomic imprinting, and X chromosome inactivation. Dr. Jaenisch’s mouse models have produced important advances in understanding cancer, neurological disorders, connective tissue diseases, and developmental abnormalities in muscle and bone. One of the most intriguing models, involving an enzyme called DNA methyltransferase (Mtase), has led to a potential new strategy for cancer therapy. Other models could speed the development of new drugs to fight Alzheimer’s disease or amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig’s disease).
. 1996 Boehringer Mannheim Molecular Bioanalytics Prize
. 2001 Peter Gruber Foundation Award in Genetics
. 2002 Robert Koch Prize for Excellence in Scientific Achievement
. 2003 Charles Rodolphe Brupbacher Prize for basic research in oncology
Jackson-Grusby, L., Beard, C., Possemato, R., Fambrough, D., Csankovszki, G., Dausman, J., Lee, P., Wilson, C., Lander, E. and Jaenisch, R. (2001). Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation. Nature Genet. 27, 31-39.
Eggan, K., Akutsu, H., Hochedlinger, K., Rideout, W., Yanagimachi, R., and Jaenisch, R. (2000). X chromosome inactivation in cloned embryos. Science 290, 1578-1581.
Rideout, W.M., Eggan, K., and Jaenisch, R. (2001). Nuclear cloning and epigenetic reprogramming of the genome. Science 293, 1093-1098.
Hochedlinger, K. and Jaenisch, R. Generation of monoclonal mice by nuclear transfer from mature B and T donor cells. (2002). Nature 415, 2124-2135.
Rideout, W.M., Hochedlinger, K., Kyba, M., Daley, G.Q., and Jaenisch, R. (2002). Correction of a genetic defect by nuclear transplantation and combined cell and gene therapy. Cell 109, 17-27.