BARRE-SINOUSSI, FRANCOISE / Medicine / Researchers

International Center for Scientific Research

Researchers

Medicine / BARRE-SINOUSSI, FRANCOISE

fbarrepasteur.fr

Position

Professor and Director, Regulation of Retroviral Infections Unit, Virology Department, Institut Pasteur, Paris, France.

Research interests

Françoise BARRÉ-SINOUSSI, PhD, is the acting Director of the "Regulation of Retroviral Infections" Unit, at the Institut Pasteur in Paris. She is involved in retrovirology research, since the early 1970's. She is recognized for her contributions to HIV/AIDS research, in particular as the first author of the publication that reported in 1983 the discovery of a retrovirus, later named HIV, in a patient at risk for AIDS. In 1988, she became responsible of her own laboratory at the Institut
Pasteur and initiated research programs on viral and host determinants of HIV / AIDS pathogenesis.
Between 1988 and 1998, she has also been implicated in collaborative programs on HIV vaccine research, using primate models. Today, the research programs of her team are focused on regulations of HIV / SIV infection (intracellular
restrictions of HIV-1infection and innate immunity, in particular regulations of T cell activation resulting from the NKdendritic cell interplay).

Prizes and awards

Nobel Prize in Physiology or Medicine for 2008, jointly with Luc Montagnier for their discovery of "human immunodeficiency virus"

1985 : Galien Prize for the Viral Oncology Unit of the Pasteur Institute (France)
1985 : Sovac Prize for the Viral Oncology Unit of the Pasteur Institute (France)
1986 : Förderpreis für die Europaische Wissenschaft, (Körber Stiftung) (Germany)
1988 : Award of the French Academy of Medicine (France)
1990 : Chevalier of Order of Merit (France)
1991 : Prize "Madame Europe Club V.R.A.I." (France)
1993 : King Faisal International Prize of Medicine (AcquiredImmunodeficiencyDiseases) (Saudi Arabia)
1993 : Prize Medicine and Research of the Institute of Sciences of the Health, Paris (France)
1996 : Chevalier of the Legion of Honour (France)
2001 : Emeritus award of the International AIDS Society (IAS)
2002 : Officer of Order of Merit (France)
2003 : ARRI award in Biomedical Sciences
2006 : Officer of the Legion of Honour (France)
2007 : Women in Technology International (WITI) Hall of Fame recipient
2008 : Honorary Doctorate of Medicine of Tulane University

Publications

1. BARRÉ-SINOUSSI F., CHERMANN J.-C., REY F., NUGEYRE M.-T., CHAMARET S., GRUEST J., DAUGUET C., AXLERBLIN C., BRUN-VEZINET F., ROUZIOUX C., ROZENBAUM W. & MONTAGNIER L. Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS).
Science, 1983, 220, 868-871.

2. F. SIMON, Ph. MAUCLERE, P. ROQUES, I. LOUSSERT-AJAKA, M.C. MÜLLER-TRUTWIN, S. SARAGOSTI, M.-C. GEORGES-COURBOT, F. BARRÉ-SINOUSSI & F. BRUN-VÉZINET. Identification of a new human immunodeficiency virus type 1 distinct from group M and group O.
Nature & Med., 1998, 4, 1032-1037.

3. D.SCOTT-ALGARA, LX.TRUONG, P.VERSMISSE, A. DAVID, T.T. LUONG, N.V. NGUYEN, I. THEODOROU, F. BARRE-SINOUSSI & G. PANCINO. Increased NK Cell Activity in HIV-1 Exposed but Uninfected Vietnamese Intravascular Drug users
J. Immunology 2003, 171 :5663-5667

4. KORNFELD C, PLOQUIN MJ, PANDREA I, FAYE A, ONANGA R, APETREI C, POATY-MAVOUNGOU V, ROUQUET P, ESTAQUIER J, MORTARA L, DESOUTTER JF, BUTOR C, LE GRAND R, ROQUES P, SIMON F, BARRE-SINOUSSI F, DIOP OM, MULLER-TRUTWIN MC. Antiinflammatory profiles during primary SIV infection in African green monkeys are associated with protection against AIDS.
J. Clin. Invest. 2005. 115 (4): 1082-1091

5. BEQ S., NUGEYRE M-T., HO TSONG FANG R., GAUTIER D., LEGRAND R., SCHMITT N., ESTAQUIER J., BARRÉ-SINOUSSI F., HURTREL B., CHEYNIER R. AND ISRAËL N. IL-7 Induces Immunological Improvement in SIV-Infected Rhesus Macaques under Antiviral Therapy.
J. Immunol. 2006 ; 176 : 914-922.

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