Institute Professor and Director of the McGovern Institute for Brain Research, Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, USA.
His research interests have centered on the molecular biology of gene expression relevant to cancer and the mechanisms of RNA splicing; his landmark achievement was the discovery of RNA splicing in 1977. This work provided one of the first indications of the startling phenomenon of ìdiscontinuous genesî in mammalian cells. The discovery that genes contain nonsense segments that are edited out by cells in the course of utilizing genetic information is important in understanding the genetic causes of cancer and other diseases. Dr. Sharpís research opened an entirely new area in molecular biology and forever changed the field. For this work he shared the 1993 Nobel Prize in Physiology or Medicine with Dr. Richard Roberts who did work in parallel at Cold Spring Harbor.
2002: The Fourth Annual Biotechnology Heritage Medal, Chemical Heritage Foundation
2001: Honorary Doctorate from Northern Kentucky University
2001: The Walker Prize from the Museum of Science, Boston, MA
1999: The Benjamin Franklin Medal of the American Philosophical Society
1993: The Nobel Prize in Physiology or Medicine
1993: The James R. Killian, Jr., Faculty Achievement Award, MIT
1993: The Mendel Medal Award from Villanova University, Villanova, PA
1990: The Dickson Prize, University of Pittsburgh
1988: The Albert Lasker Basic Medical Research Award
1988: Louisa Gross Horwitz Prize, Columbia University
1986: The New York Academy of Sciences Award in Biological and Medical Sciences
1986: The Gairdner Foundation International Award, Canada
1986: The General Motors Research Foundation Alfred P. Sloan, Jr. Prize for Cancer Research
1985: The Howard Ricketts Award, The University of Chicago
1980: The Eli Lilly Award in Biological Chemistry
1980: The National Academy of Sciences' U.S. Steel Foundation Award in Molecular Biology
1 : Transcription-coupled and DNA damage-dependent ubiquitination of RNA polymerase II in vitro.
Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4239-44.
2: Mouse lymphoid cell line selected to have high immunoglobulin promoter activity.
Mol Cell Biol. 2002 Mar;22(5):1460-73.
3: RNA interference--2001.
Genes Dev. 2001 Mar 1;15(5):485-90.
4: A ribozyme selected from variants of U6 snRNA promotes 2',5'-branch formation.
RNA. 2001 Jan;7(1):29-43.
5: Positive transcription elongation factor B phosphorylates hSPT5 and RNA polymerase II carboxyl-terminal domain independently of cyclin-dependent kinase-activating kinase.
J Biol Chem. 2001 Apr 13;276(15):12317-23.